Recruiting

Gene Expression Profiling

Sponsor:

Brigham and Women's Hospital

Code:

NCT00833313

Conditions

Atrial Fibrillation

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

Atrial biopsy

Study Details

Brief summary:

Atrial fibrillation is a type of irregular heartbeat that is common after having heart surgery. There may be many different reasons why some people get atrial fibrillation after their heart surgery. These reasons may include that a person is older or that he/she is taking certain types of medications before surgery. Genes may also be a reason. Genes contain the material passed from parent to child that determines the make-up of the body and mind. For example, some genes control the color of your hair or eyes. Some people may have genes that make it more likely for them to get atrial fibrillation after their heart surgery. This research project is being done to find out if the cells of people who develop atrial fibrillation after heart surgery are different from the cells in people who do not develop atrial fibrillation after surgery.

Conditions

Atrial Fibrillation

Study ID

NCT00833313

Start date

Aug, 2008

Status verified date

Feb, 2023

Completion date

Aug, 2025

Anticipated

Primary completion date

Aug, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 20-99 years
  • Undergoing cardiac surgery

Exclusion Criteria:

  • Prior cardiac surgery
  • chest radiation
  • recent chemotherapy

Study Design

Enrollment

350 participants

Anticipated

Interventions and Outcome Measures

Interventions

Atrial biopsy

Biopsy of left atrial free wall and possibly left atrial appendage

Primary outcome measure

  • Gene expression [ Time Frame: Immediate ]

Central Contacts and Locations

Central contacts

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Jochen D Muehlschlegel, MD, MMSc

617-732-7330jmuehlschlegel@bwh.harvard.edu

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Feb 8, 2023

Last verified

Feb, 2023

Keywords

  • Atrial fibrillation
  • Gene expression
  • Genetic

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2023-02-08.