Recruiting

Tissue Samples

Sponsor:

Vanderbilt-Ingram Cancer Center

Code:

NCT00897117

Conditions

Lung Cancer

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

gene expression analysis

microarray analysis

protein expression analysis

biologic sample preservation procedure

laboratory biomarker analysis

Study Details

Brief summary:

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer.

PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.

Conditions

Lung Cancer

Study ID

NCT00897117

Start date

May 1, 2001

Status verified date

Aug, 2026

Completion date

May 31, 2031

Anticipated

Primary completion date

May 31, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion criteria

  • Diagnosis of non-small cell lung cancer

  • Clinical stage I and II disease
  • Resectable disease and complete surgical resection planned
  • Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network
  • Tumor specimen samples must be available at resection

Exclusion criteria

  • Chemotherapy before surgery
  • Radiotherapy before surgery

Study Design

Enrollment

4000 participants

Anticipated

Interventions and Outcome Measures

Arms

Resectable non-small cell lung cancer

Patients with clinical stage I or II invasive lung cancer that can be completely removed by surgery and who have not undergone chemotherapy or radiotherapy before surgery

Interventions

gene expression analysis

Blood and lung tissue collection

microarray analysis

Blood and lung tissue collection

protein expression analysis

Blood and lung tissue collection

biologic sample preservation procedure

Blood and lung tissue collection

laboratory biomarker analysis

Blood and lung tissue collection

matrix-assisted laser desorption/ionization time of flight mass spectrometry

Blood and lung tissue collection

Primary outcome measure

  • Protein and RNA expression fingerprints from collected samples [ Time Frame: after collection of designated samples ]

Central Contacts and Locations

Central contacts

VICC Clinical Trials Information Program

800-811-8480cip@vumc.org

Locations

Vanderbilt-Ingram Cancer Center

Recruiting

Nashville, Tennessee, United States, 37232-6838

Contacts

Clinical Trials Office - Vanderbilt-Ingram Cancer Center

800-811-8480

More Information

Sponsor

Vanderbilt-Ingram Cancer Center

Last update posted

Aug 20, 2026

Last verified

Aug, 2026

Keywords

  • stage I non-small cell lung cancer
  • stage II non-small cell lung cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt-Ingram Cancer Center on 2026-08-20.