Recruiting

Observational Study

Sponsor:

Vanderbilt University Medical Center

Code:

NCT00898638

Conditions

Head and Neck Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

biologic sample preservation procedure

medical chart review

Study Details

Brief summary:

RATIONALE: Collecting and storing samples of tissue, saliva, and blood from patients with cancer and from healthy participants to study in the laboratory may help the study of cancer in the future.

PURPOSE: This research study is collecting and storing tissue samples from patients with head and neck cancer and from healthy participants.

Conditions

Head and Neck Cancer

Study ID

NCT00898638

Start date

Feb 13, 2003

Status verified date

Oct, 2025

Completion date

Dec, 2050

Anticipated

Primary completion date

Dec, 2050

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

DISEASE CHARACTERISTICS:

  • Meets 1 of the following criteria:

  • Diagnosis of head and neck cancer
  • Being treated at Vanderbilt University Medical Center for the cancer
  • Healthy participant

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified

Study Design

Enrollment

8000 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy Volunteers

Non-tumor volunteers will be asked to participate at the time that they are attending a head and neck cancer screening clinic or at the time they are accompanying a patient to their appointment at the head and neck clinic. Intake sheets and biological specimens contributed by volunteers will be coded at the time of collection so that no identifiers are obtained. These specimens will not be linked to identifiers.

Head and Neck Tumor patients

Eligible patients will be identified at the Vanderbilt Head \& Neck Clinic by clinical and research staff. An appropriately trained staff member will discuss the protocol with the patient (including, risks, benefits, alternatives, etc.).

Interventions

biologic sample preservation procedure

medical chart review

Primary outcome measure

  • Maintenance of a clinical database pertaining to diagnosis and treatment outcome of patients with head and neck cancer [ Time Frame: ongoing ]
  • Development of a repository of biospecimens [ Time Frame: ongoing ]

Central Contacts and Locations

Central contacts

Brandee Brown

615-936-4896brandee.t.brown@vumc.org

Locations

Vanderbilt-Ingram Cancer Center - Cool Springs

Recruiting

Nashville, Tennessee, United States, 37064

Contacts

Eben Rosenthal, MD

800-811-8480

Vanderbilt-Ingram Cancer Center at Franklin

Recruiting

Nashville, Tennessee, United States, 37064

Contacts

Eben Rosenthal, MD

800-811-8480

Veterans Affairs Medical Center - Nashville

Recruiting

Nashville, Tennessee, United States, 37212

Contacts

Clinical Trials Office - Veterans Affairs Medical Center - Nas

615-327-4751

Vanderbilt-Ingram Cancer Center

Recruiting

Nashville, Tennessee, United States, 37232-6838

Contacts

Clinical Trials Office - Vanderbilt-Ingram Cancer Center

800-811-8480

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Oct 28, 2025

Last verified

Oct, 2025

Keywords

  • stage I squamous cell carcinoma of the hypopharynx
  • stage II squamous cell carcinoma of the hypopharynx
  • stage III squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the hypopharynx
  • recurrent squamous cell carcinoma of the hypopharynx
  • stage I squamous cell carcinoma of the larynx
  • stage I verrucous carcinoma of the larynx
  • stage II squamous cell carcinoma of the larynx
  • stage II verrucous carcinoma of the larynx
  • stage III squamous cell carcinoma of the larynx
  • stage III verrucous carcinoma of the larynx
  • stage IV squamous cell carcinoma of the larynx
  • stage IV verrucous carcinoma of the larynx
  • recurrent squamous cell carcinoma of the larynx
  • recurrent verrucous carcinoma of the larynx
  • stage I adenoid cystic carcinoma of the oral cavity
  • stage I basal cell carcinoma of the lip
  • stage I mucoepidermoid carcinoma of the oral cavity
  • stage I squamous cell carcinoma of the lip and oral cavity
  • stage I verrucous carcinoma of the oral cavity
  • stage II adenoid cystic carcinoma of the oral cavity
  • stage II basal cell carcinoma of the lip
  • stage II mucoepidermoid carcinoma of the oral cavity
  • stage II squamous cell carcinoma of the lip and oral cavity
  • stage II verrucous carcinoma of the oral cavity
  • stage III adenoid cystic carcinoma of the oral cavity
  • stage III basal cell carcinoma of the lip
  • stage III mucoepidermoid carcinoma of the oral cavity
  • stage III squamous cell carcinoma of the lip and oral cavity
  • stage III verrucous carcinoma of the oral cavity
  • stage IV adenoid cystic carcinoma of the oral cavity
  • stage IV basal cell carcinoma of the lip
  • stage IV mucoepidermoid carcinoma of the oral cavity
  • stage IV squamous cell carcinoma of the lip and oral cavity
  • stage IV verrucous carcinoma of the oral cavity
  • recurrent adenoid cystic carcinoma of the oral cavity
  • recurrent basal cell carcinoma of the lip
  • recurrent mucoepidermoid carcinoma of the oral cavity
  • recurrent squamous cell carcinoma of the lip and oral cavity
  • recurrent verrucous carcinoma of the oral cavity
  • metastatic squamous neck cancer with occult primary squamous cell carcinoma
  • recurrent metastatic squamous neck cancer with occult primary
  • untreated metastatic squamous neck cancer with occult primary
  • stage I lymphoepithelioma of the nasopharynx
  • stage I squamous cell carcinoma of the nasopharynx
  • stage II lymphoepithelioma of the nasopharynx
  • stage II squamous cell carcinoma of the nasopharynx
  • stage III lymphoepithelioma of the nasopharynx
  • stage III squamous cell carcinoma of the nasopharynx
  • stage IV lymphoepithelioma of the nasopharynx
  • stage IV squamous cell carcinoma of the nasopharynx
  • recurrent lymphoepithelioma of the nasopharynx
  • recurrent squamous cell carcinoma of the nasopharynx
  • stage I lymphoepithelioma of the oropharynx
  • stage I squamous cell carcinoma of the oropharynx
  • stage II lymphoepithelioma of the oropharynx
  • stage II squamous cell carcinoma of the oropharynx
  • stage III lymphoepithelioma of the oropharynx
  • stage III squamous cell carcinoma of the oropharynx
  • stage IV lymphoepithelioma of the oropharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • recurrent lymphoepithelioma of the oropharynx
  • stage I esthesioneuroblastoma of the paranasal sinus and nasal cavity
  • stage I inverted papilloma of the paranasal sinus and nasal cavity
  • stage I midline lethal granuloma of the paranasal sinus and nasal cavity
  • stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage II esthesioneuroblastoma of the paranasal sinus and nasal cavity
  • stage II inverted papilloma of the paranasal sinus and nasal cavity
  • stage II midline lethal granuloma of the paranasal sinus and nasal cavity
  • stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage III esthesioneuroblastoma of the paranasal sinus and nasal cavity
  • stage III inverted papilloma of the paranasal sinus and nasal cavity
  • stage III midline lethal granuloma of the paranasal sinus and nasal cavity
  • stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IV esthesioneuroblastoma of the paranasal sinus and nasal cavity
  • stage IV inverted papilloma of the paranasal sinus and nasal cavity
  • stage IV midline lethal granuloma of the paranasal sinus and nasal cavity
  • stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
  • recurrent esthesioneuroblastoma of the paranasal sinus and nasal cavity
  • recurrent inverted papilloma of the paranasal sinus and nasal cavity
  • recurrent midline lethal granuloma of the paranasal sinus and nasal cavity
  • recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage I salivary gland cancer
  • stage II salivary gland cancer
  • stage III salivary gland cancer
  • stage IV salivary gland cancer
  • recurrent salivary gland cancer
  • recurrent squamous cell carcinoma of the oropharynx

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2025-10-28.