Recruiting

Observational Study

Sponsor:

Vanderbilt University Medical Center

Code:

NCT00899626

Conditions

Colorectal Cancer

Esophageal Cancer

Gastric Cancer

Pancreatic Cancer

Precancerous Condition

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

RATIONALE: Studying samples of tissue, blood, urine, stool, and other biological fluids from patients with cancer and from healthy volunteers undergoing colonoscopy or endoscopy may help doctors identify and learn more about biomarkers related to cancer.

PURPOSE: This research study is looking at gastrointestinal biomarkers in tissue and biological fluid samples from patients and participants undergoing colonoscopy, endoscopy, or surgery.

Conditions

Colorectal Cancer

Esophageal Cancer

Gastric Cancer

Pancreatic Cancer

Precancerous Condition

Study ID

NCT00899626

Start date

Jun, 2002

Status verified date

Mar, 2026

Completion date

Oct, 2045

Anticipated

Primary completion date

Oct, 2045

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

DISEASE CHARACTERISTICS:

  • Undergoing colonoscopy or endoscopy for diagnostic or screening purposes at the Vanderbilt University Medical Center or at the Veterans Affairs Medical Center AND
  • Meets 1 of the following criteria:

  • Diagnosis of gastrointestinal (GI) cancer, polyps, or inflammatory bowel disease
  • History of previously treated GI cancer, polyps, or inflammatory bowel disease

PATIENT CHARACTERISTICS:

  • Capable of giving informed consent
  • Not mentally or medically impaired
  • No bleeding disorder

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

Study Design

Enrollment

5000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Identification of new potential biomarkers of increased gastrointestinal cancer risk using tissue and biofluid samples from patients undergoing colonoscopy, endoscopy, or surgery [ Time Frame: Through study completion, approximately 30 years ]
  • Development of new screening strategies based on substances found in tissue and biofluid samples [ Time Frame: Through study completion, approximately 30 years ]

Central Contacts and Locations

Central contacts

Kristen K Ciombor, MD

6159368422kristen.k.ciombor@vumc.org

Keeli B Lewis, BS

keeli.b.lewis@vumc.org

Locations

Veterans Affairs Medical Center - Nashville

Recruiting

Nashville, Tennessee, United States, 37212

Contacts

Clinical Trials Office - Veterans Affairs Medical Center - Nas

615-327-4751

Vanderbilt-Ingram Cancer Center

Recruiting

Nashville, Tennessee, United States, 37232-6838

Contacts

Clinical Trials Office - Vanderbilt-Ingram Cancer Center

800-811-8480

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Keywords

  • colon cancer
  • gastric cancer
  • pancreatic cancer
  • esophageal cancer
  • adenomatous polyp

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2026-03-05.