Recruiting

Observational Study

Sponsor:

Brigham and Women's Hospital

Code:

NCT00985049

Conditions

Cardiovascular Diseases

Eligibility Criteria

Sex: All

Age: 20+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Conditions

Cardiovascular Diseases

Study ID

NCT00985049

Start date

Mar, 2009

Status verified date

Aug, 2024

Completion date

Dec, 2025

Anticipated

Primary completion date

Dec, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aged greater than 20 years
  • Undergoing aortic valve surgery with or without CABG surgery
  • Receive and apical vent as part of the surgery

Exclusion Criteria:

  • Will not receive an apical left ventricular vent

Study Design

Enrollment

350 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Differential gene expression [ Time Frame: Immediate ]

Central Contacts and Locations

Central contacts

Jochen D Muehlschlegel, MD, MMSc, MBA

4109558408dmuehlsch@jhu.edu

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Sergey Karamnov, MD

skaramnov@bwh.harvard.edu

Principal Investigator:

Sergey Karamnov, MD

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Aug 22, 2024

Last verified

Aug, 2024

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2024-08-22.