Recruiting

Genetics

Sponsor:

National Jewish Health

Code:

NCT01088217

Conditions

Idiopathic Pulmonary Fibrosis

Familial Pulmonary Fibrosis

Idiopathic Interstitial Pneumonia

Familial Interstitial Pneumonia

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis.

Conditions

Idiopathic Pulmonary Fibrosis

Familial Pulmonary Fibrosis

Idiopathic Interstitial Pneumonia

Familial Interstitial Pneumonia

Study ID

NCT01088217

Start date

Jul, 2008

Status verified date

Sep, 2020

Completion date

Jun, 2025

Anticipated

Primary completion date

Jun, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Two or more family members with a clinical diagnosis of Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
  • Additional family members may be eligible to participate if two family members are suspected of or diagnosed as having Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)

Exclusion Criteria:

  • Individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic
  • Individuals whose pulmonary fibrosis is due to a broader genetic syndrome

Study Design

Enrollment

8000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Identify a group of genetic loci that play a role in the development of familial interstitial pneumonia and idiopathic interstitial pneumonia. [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Julie Powers, MHS

303-724-6539julia.powers@ucdenver.edu

Janet Talbert, MS, CGC

1-800-423-8891talbertj@njhealth.org

Locations

University of Colorado Denver

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Julie Powers, MHS

303-724-6539julia.powers@ucdenver.edu

Janet Talbert, MS, CGC

1-800-423-8891talbertj@njhealth.org

Principal Investigator:

David A. Schwartz, MD

National Jewish Health and University of Colorado Denver

Recruiting

Denver, Colorado, United States, 80206

Contacts

Janet Talbert, MS, CGC

800-423-8891talbertj@njhealth.org

Julie Powers, MHS

303-724-6539julia.powers@ucdenver.edu

Principal Investigator:

David A. Schwartz, MD

Vanderbilt University

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Cheryl Markin, MT

888-898-1550cheryl.markin@vanderbilt.edu

Principal Investigator:

James E. Loyd, MD

More Information

Sponsor

National Jewish Health

Last update posted

Sep 14, 2020

Last verified

Sep, 2020

Keywords

  • Idiopathic Pulmonary Fibrosis
  • Familial Pulmonary Fibrosis
  • Idiopathic Interstitial Pneumonia
  • Familial Interstitial Pneumonia
  • Pulmonary Fibrosis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Jewish Health on 2020-09-14.