Recruiting

Gene Mutations

Sponsor:

Massachusetts General Hospital

Code:

NCT01098929

Conditions

Congenital Diaphragmatic Hernia

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Congenital diaphragmatic hernia (CDH) occurs when the diaphragm, the muscle that separates the chest cavity from the abdominal cavity, does not form properly. When an opening is present in the diaphragm, organs that are normally found in the abdomen can move up into the chest cavity. The primary objective of this study is to generate information about the hereditary basis of congenital diaphragmatic hernia and abnormal lung development. Our long-term goal is to identify ways to treat babies in utero with effective but safe drugs to speed up lung development before birth.

Conditions

Congenital Diaphragmatic Hernia

Study ID

NCT01098929

Start date

Jul, 2002

Status verified date

Dec, 2015

Completion date

Jul, 2017

Anticipated

Primary completion date

Jul, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

All individuals affected with a congenital diaphragmatic hernia (CDH), or with a family history of CDH

Exclusion Criteria:

Individuals with no personal or family history of a CDH

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Congenital Diaphragmatic Hernia (CDH)

Individuals affected with congenital diaphragmatic hernia (CDH)

Unaffected

Healthy family members of individuals affected with congenital diaphragmatic hernia (CDH)

Primary outcome measure

  • identify genes associated with CDH [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Jessica Kim, BS

617-355-2555jessica.kim2@childrens.harvard.edu

Locations

Children's Hospital Boston

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Jessica Kim, BS

617-355-2555jessica.kim2@childrens.harvard.edu

Principal Investigator:

Jay Wilson, MD

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Dec 17, 2015

Last verified

Dec, 2015

Keywords

  • genes
  • genetic
  • chromosome
  • chromosome microarray

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2015-12-17.