Recruiting

Tissue Repository

Sponsor:

National Cancer Institute (NCI)

Code:

NCT01109394

Conditions

Sarcoma

Endocrine Tumors

Neuroblastoma

Retinoblastoma

Renal Cancer

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Background:

\- Laboratory investigators who are studying common childhood cancers are interested in developing a tissue repository to collect and store blood, serum, tissue, urine, or tumors of children who have cancer or adults who have common childhood cancers. To develop this repository, additional samples will be collected from children and adults who have been diagnosed with common childhood cancers such as leukemia and tumors of the central nervous system.

Objectives:

\- To collect and store blood, serum, tissue, urine, or tumor samples of children who have cancer or adults who have common childhood cancers.

Eligibility:

  • Individuals who have been diagnosed with a common childhood cancer (e.g., leukemia) regardless of patient age.
  • Children, adolescents, and adults who have been diagnosed with a type of cancer more commonly found in adults.

Design:

  • Extra blood, serum (the liquid part of blood), tissue, urine, or tumor samples will be collected from participants at a time when sampling is required for medical care or as part of a research study.
  • No additional procedures will be performed for the sole purpose of obtaining additional tumor tissue, aside from what is required for clinical care.

Conditions

Sarcoma

Endocrine Tumors

Neuroblastoma

Retinoblastoma

Renal Cancer

Study ID

NCT01109394

Start date

Apr 21, 2010

Status verified date

Aug 31, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

  • SUBJECT INCLUSION CRITERIA:

Pediatric or adult subjects with one of the following:

  • Diagnosis of any tumor, malignancy, pre-malignant disorder, or suspected premalignant familial syndromes, regardless, of patient age;
  • Biological relatives of any patient with a tumor, malignancy, pre-malignant disorder, or suspected familial pre-malignant syndrome, regardless of patient age or the diagnosis of an adult malignancy or pre-malignant disorder;
  • Healthy Volunteer without history of malignancy nor a family member currently being treated for cancer who are undergoing surgery, treatment or during well visits;
  • Biospecimens can be collected with minimal additional risk to the subject during sampling or procedures required for routine patient care.
  • Human samples, specimens and data collected on IRB approved protocols that are now closed
  • Ability of subject, Legally Authorized Representative (LAR), or parent/legal guardian of children <=18 to understand and be willing to sign an IRB-approved informed consent document that permits the use of the tumor and other samples for genomic-based molecular characterization projects.

Inclusion Criteria for Social and Behavioral Outcome Interviews:

  • Parent/caregiver of a participating pediatric or adult patient who is being treated for, or who has previously been treated for any form of pediatric cancer.
  • Must be able to give consent and sign the informed consent document.
  • Able to understand the English language.

EXCLUSION CRITERIA:

None

Study Design

Enrollment

6035 participants

Anticipated

Interventions and Outcome Measures

Arms

1/Cohort 1

Adult or Pediatric subjects, with any malignancy, pre-malignancy, suspected malignancy, family history of malignancy, or without malignancy undergoing surgery or well visit.

2/Cohort 2

Human samples, specimens and data collected on IRB approved protocols that are now closed

3/Cohort 3

Parent/caregiver of a participating pediatric or adult subject who is being treated for, or who has previously been treated for any form of pediatric cancer.

Primary outcome measure

  • tissue analysis [ Time Frame: ongoing ]

Central Contacts and Locations

Central contacts

Donna B Bernstein, R.N.

(240) 760-6189bernsted@mail.nih.gov

Rosandra N Kaplan, M.D.

(240) 760-6198kaplanrn@mail.nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Cancer Institute (NCI)

Last update posted

Sep 4, 2026

Last verified

Aug 31, 2026

Keywords

  • Genomics
  • Proteomics
  • Tissue Repository
  • Omics
  • Cell Lines
  • Natural History
  • Pediatric Cancer
  • Solid Tumor
  • Sarcoma
  • Kidney Cancer
  • Neuroblastoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by National Cancer Institute (NCI) on 2026-09-04.