Recruiting

Observational Study

Sponsor:

Brigham and Women's Hospital

Code:

NCT01177618

Conditions

Chronic Obstructive Pulmonary Disease

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Chronic obstructive pulmonary disease (COPD) is often caused by cigarette smoking, but genetic predisposition also influences COPD susceptibility. The purpose of this study is to identify genetic factors that predispose some individuals to develop COPD.

Conditions

Chronic Obstructive Pulmonary Disease

Study ID

NCT01177618

Start date

Jul, 1994

Status verified date

Oct, 2025

Completion date

Jul, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria for Early-Onset COPD Probands:

  • Early onset of COPD in individuals younger than 53 years old
  • Spirometry results that are indicative of severe COPD (FEV1 < 40% predicted)
  • Physician-diagnosed COPD

Exclusion Criteria for Early-Onset COPD Probands:

  • Severe alpha-1 antitrypsin deficiency
  • Other chronic lung diseases in participants with COPD (except asthma)
  • Pregnant
  • Any previous lung surgery including lung transplant or lung reduction volume surgery (LVRS); unless prior Pulmonary Function Tests are available

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Arms

Probands

Severe, early-onset COPD subjects that bring the family into the study

Relatives

Relatives of early-onset COPD probands, including first-degree relatives (parents, siblings, and children), second-degree relatives (aunts, uncles, grandparents, half-siblings), spouses, and other affected individuals.

Primary outcome measure

  • No Primary Outcome [ Time Frame: Single Visit for approximately two hours to collect study data and samples ]

Central Contacts and Locations

Central contacts

Edwin K. Silverman, M.D., Ph.D.

617-525-2128ed.silverman@channing.harvard.edu

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Edwin Silverman

617-525-0856ed.silverman@channing.harvard.edu

Violet Richardson

617-525-2128advri@channing.harvard.edu

Principal Investigator:

Edwin K. Silverman, M.D., Ph.D.

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Oct 24, 2025

Last verified

Oct, 2025

Keywords

  • Chronic Obstructive Pulmonary Disease
  • COPD
  • Emphysema
  • Chronic Bronchitis
  • Genetics
  • Association Studies

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-26. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2025-10-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.