Recruiting

Observational Study

Sponsor:

Orasi Medical, Inc.

Code:

NCT01185990

Conditions

Tinnitus

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The study is designed to identify specific patterns of brain functional activity associated with chronic, moderate to severe tinnitus through the use of resting-state MEG scans. Robust patterns identified in this study will be used as a biomarker for subsequent clinical evaluation of experimental drug treatments for tinnitus. This study will conduct MEG scans on approximately 30 to 75 subjects with tinnitus and approximately 15 healthy control subjects. MEG scans will be obtained for each subject following screening, clinical and tinnitus evaluations. A subset of 6 subjects from the tinnitus cohort will be invited to undergo evoked auditory assessment during an extended MEG scan session to identify cortical regions that respond to the auditory stimulus. These six subjects also will be evaluated with a single structural MRI scan to support high-resolution mapping of the localized cortical regions. MEG data will be analyzed to identify patterns of brain activity that are specifically associated with the presence of tinnitus using both standard approaches and the Orasi Synchronous Neural Interaction™ (SNI) test. MEG scan results also will be evaluated to identify specific patterns of functional activity that correlate with other measures of tinnitus severity such as the Iowa Tinnitus Handicap Scale. This study will test the hypothesis that moderate to severe tinnitus is associated with altered patterns of brain functional activity measured by a brief, resting-state MEG scan. This hypothesis will be tested by comparing resting-state MEG scans of tinnitus patients with those the of healthy control subjects collected during this study and available in Orasi's existing MEG scan database.

Conditions

Tinnitus

Study ID

NCT01185990

Start date

Aug, 2010

Status verified date

Mar, 2011

Completion date

Aug, 2011

Anticipated

Primary completion date

Aug, 2011

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subject is between 18 and 75 years of age at the time of screening.
  • Subject understands the study procedures and agrees to participate in the study by giving written informed consent.
  • Subject is a non-smoker.
  • Subject is judged to be in good health based on medical history and brief physical examination.
  • Subject has a diagnosis of chronic, moderate to severe (Tinnitus Handicap Inventory score range of 38 - 76, inclusive), unilateral tinnitus of unknown etiology, or is participating in the study as a healthy control subject.

Exclusion Criteria:

  • Subject has severe hearing impairment, external or middle ear diseases or temporomandibular joint disorders.
  • Subject has a diagnosis of a significant neurological condition including Alzheimer's disease, Parkinson's disease, vascular dementia, Lewy body dementia or frontal temporal dementia, human immunodeficiency virus, multiple sclerosis, or severe traumatic brain injury.
  • Subject has a history of primary psychotic disorder (e.g. schizophrenia, schizoaffective disorder, delusional disorder) or bipolar disorder.
  • Subject has a history of seizures, epilepsy, stroke, peripheral neuropathy, head trauma with persistent post-concussive symptoms, ADHD, dyslexia or other clinically significant neurological disease or cognitive impairment.
  • Subject has a current episode of major depressive disorder.
  • Subject has used antidepressants, anxiolytics, antipsychotics or antiepileptic medications in the past 6 months.
  • Subject has a recent (within 2 years) history of alcohol or substance abuse/dependence.
  • Subject has completed an MRI within 2 weeks prior to the MEG scan.
  • Subject has metal braces or pacemaker that may interfere with the MEG scan.
  • Subject is unable to complete the MEG scan procedure.
  • The investigator has any concern regarding the safe participation of a subject in the study, or if for any other reason the investigator considers the subject inappropriate for study participation

Study Design

Enrollment

45 participants

Anticipated

Interventions and Outcome Measures

Arms

Tinnitus subjects

Subjects with chronic, moderate to severe unilateral tinnitus.

Healthy control subjects

Primary outcome measure

  • Correlated brain activity [ Time Frame: 1 day ]

Central Contacts and Locations

Locations

Noran Neurological Clinic

Recruiting

Minneapolis, Minnesota, United States, 55407

Contacts

Ann Rechtzigel, BSN

612-708-5357rex5@frontiernet.net

Principal Investigator:

Richard E Golden, MD

Radiant Research

Recruiting

Minneapolis, Minnesota, United States, 55435

Contacts

Anne-Marie Tschida

952-922-7000anne-marietschida@radiantresearch.com

Principal Investigator:

Tami Helmer, MD

More Information

Sponsor

Orasi Medical, Inc.

Last update posted

Mar 23, 2011

Last verified

Mar, 2011

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-29. This information was provided to ClinicalTrials.gov by Orasi Medical, Inc. on 2011-03-23. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.