Recruiting

Cortical Stimulation

Sponsor:

University of Washington

Code:

NCT01198964

Conditions

Epilepsy

Brain Injury

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Low-level cortical stimulation

Study Details

Brief summary:

We will observe epileptic patients who already have electrodes implanted on the brain and are receiving high-level brain stimulation for clinical purposes while testing their motor and language function. We propose to do a limited, low-level brain stimulation to show that the signatures of local activity in the target area change as an effect of brain stimulation. The goal of this study is to understand the feasibility of a novel recurrent brain-computer interface that could eventually promote targeted functional recovery in subjects who have had a brain injury.

Conditions

Epilepsy

Brain Injury

Study ID

NCT01198964

Start date

Sep, 2010

Status verified date

Apr, 2021

Completion date

Aug, 2023

Anticipated

Primary completion date

Aug, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 and older
  • Male and Female
  • Able to understand English for consenting and testing
  • Referred for surgical implantation of electrodes

Exclusion Criteria:

  • Under 18 years of age
  • Pregnant women
  • Prisoners
  • Mentally disabled IQ < 70
  • Non English Speaking
  • Not candidates for surgical implantation of electrodes

Study Design

Enrollment

8 participants

Anticipated

Interventions and Outcome Measures

Arms

Epileptic Patients

The population of patients with medically refractory epilepsy will already have been recommended clinically for electrode grid placement on the brain and high-level stimulation to map brain function.

Interventions

Low-level cortical stimulation

A couple of electrodes will be stimulated (at a lower level than the stimulation used for standard care) over a period of 4-12 hours based on the signals defined by the motor or language task.

Primary outcome measure

  • Link EMG activity produced during a motor task to stimulation of a part of the brain [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Jeffrey G Ojemann, MD

206-987-4240jojemann@u.washington.edu

Eberhard E Fetz, PhD

206-543-4839fetz@u.washington.edu

Locations

Harborview Medical Center

Recruiting

Seattle, Washington, United States, 98104

Contacts

Amy Anderson

206-744-9364amya9@uw.edu

Principal Investigator:

Jeffrey G Ojemann, MD

More Information

Sponsor

University of Washington

Last update posted

Apr 27, 2021

Last verified

Apr, 2021

Keywords

  • ECoG
  • Epilepsy
  • cortical
  • stimulation
  • Electrocorticography
  • electrodes
  • mapping

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Washington on 2021-04-27.