Recruiting

Genetic & EnvironmentalGenes and Environment in Multiple Sclerosis

Sponsor:

Columbia University

Code:

NCT01353547

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Conditions

Multiple Sclerosis

Study ID

NCT01353547

Start date

Oct 1, 2017

Status verified date

May, 2026

Completion date

Oct, 2040

Anticipated

Primary completion date

Oct, 2040

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

First Degree Relatives of Patients with MS, or
Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
Live in the United States

Exclusion Criteria:

Does not match any of the inclusion criteria

Study Design

Enrollment

5000 participants

Anticipated

Interventions and Outcome Measures

Arms

Received anti-TNFa therapy

First-degree relative of MS patients

First-degree relative (child, parent or sibling) of a diagnosed MS patient

A subgroup will be asked to undergo magnetic resonance imaging (MRI). Participants may be asked to donate a stool sample for gut flora analysis and a blood sample for ribonucleic acid (RNA) sequencing.

Referred by the Partners MS Center

Primary outcome measure

Total number of subjects who are diagnosed with MS [ Time Frame: 20 years ]

Central Contacts and Locations

Central contacts

Juliana Oyegunle

212-305-2434 jbo2120@cumc.columbia.edu

Locations

National Institute of Neurological Disorders and Stroke

Recruiting

Bethesda, Maryland, United States, 15213

Principal Investigator:

Daniel S Reich, MD, PhD

Columbia University Irving Center

Recruiting

New York, New York, United States, 10032

Contacts

Juliana Oyegunle

212-305-2434 jbo2120@cumc.columbia.edu

Principal Investigator:

Philip L De Jager, MD, PhD

University of Pittsburgh

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Principal Investigator:

Zongqi Xia, MD, PhD

More Information

Sponsor

Columbia University

Last update posted

May 14, 2026

Last verified

May, 2026

Keywords

genomic analysis
online surveys
biological specimen collection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2026-05-14.