Recruiting

Observational Study

Sponsor:

Columbia University

Code:

NCT01376024

Conditions

Osteoarthrosis of the Carpometacarpal Joint of the Thumb

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The data in this prospective registry will be used 1) to define which surgical and nonoperative techniques are most effective at providing pain relief, restoring function, are cost effective, and patients are satisfied with their outcomes; and 2) to design focused clinical questions regarding the optimal treatment of basal joint arthritis of the thumb in future randomized controlled trials. There are no interventions or changes in patient care associated with this study.

Conditions

Osteoarthrosis of the Carpometacarpal Joint of the Thumb

Study ID

NCT01376024

Start date

Mar 2, 2007

Status verified date

Jun, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients who have symptomatic basal joint arthritis.
  • Patients who are capable of providing informed consent.

Exclusion Criteria:

  • Patients younger than 18 years old at the time of enrollment.
  • Patients with neuromuscular disease affecting the operated hand, not caused by the CMC operation.
  • Patients with known inflammatory arthritic conditions, such as rheumatoid or psoriatic arthritis.
  • Patients with a history of or current infection of the basal joint of the affected hand.
  • Patients who are demented or are unable to provide informed consent.
  • Patients unable to comply with study guidelines.
  • Patients who have metacarpophalangeal joint hyperextension are NOT excluded. These patients will be followed and if they receive a capsulodesis or other procedure at the MCPJ at the same time as their basal joint arthroplasty this will be noted in their data records.

Study Design

Enrollment

800 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Flexion/extension range of MCP joint [ Time Frame: Baseline, 6 weeks, 3 months, 6 months, 1 year ]
  • Flexion/extension range of IP joint [ Time Frame: Baseline, 6 weeks, 3 months, 6 months, 1 year ]
  • Grip strength [ Time Frame: Baseline, 6 weeks, 3 months, 6 months, 1 year ]
  • Key-pinch strength [ Time Frame: Baseline, 6 weeks, 3 months, 6 months, 1 year ]
  • Tip-pinch strength [ Time Frame: Baseline, 6 weeks, 3 months, 6 months, 1 year ]

Central Contacts and Locations

Central contacts

Melvin P Rosenwasser, MD

212 305 8036mpr2@cumc.columbia.edu

Locations

Columbia University/NY Presbyterian Hospital

Recruiting

New York, New York, United States, 10032

Principal Investigator:

Melvin Rosenwasser, MD

More Information

Sponsor

Columbia University

Last update posted

Jun 10, 2026

Last verified

Jun, 2026

Keywords

  • Carpometacarpal arthritis
  • Basal joint arthritis
  • CMC arthritis
  • Osteoarthritis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2026-06-10.