Recruiting

Genetic Mutations

Sponsor:

Mayo Clinic

Code:

NCT01427179

Conditions

Spontaneous Coronary Artery Dissection

SCAD

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of the research is to identify mutations (defects in the genetic blueprint) that cause spontaneous coronary artery dissection (SCAD), in other words, spontaneous tears in blood vessels that supply the heart.

Some mutations may be inherited (passed on) from a parent without an apparent blood vessel problem while others may develop for the first time in the affected person.

Conditions

Spontaneous Coronary Artery Dissection

SCAD

Study ID

NCT01427179

Start date

May, 2011

Status verified date

Apr, 2026

Completion date

Dec, 2030

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and women able to give informed consent and complete a 2 page questionnaire
  • Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD)
  • Biological parent of individual with SCAD
  • Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection

Exclusion Criteria:

  • Lack of confirmation of SCAD diagnosis

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Identification of one or more gene mutation responsible for SCAD [ Time Frame: By end of study ]

Central Contacts and Locations

Central contacts

Jake Nemgar

5072663180MayoSCAD@Mayo.edu

Locations

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Jake Nemgar

507-266-3180mayoscad@mayo.edu

Principal Investigator:

Sharonne N. Hayes, M.D.

More Information

Sponsor

Mayo Clinic

Last update posted

Apr 15, 2026

Last verified

Apr, 2026

Keywords

  • Spontaneous coronary artery dissection
  • SCAD

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-04-15.