Recruiting

Genetic Analysis

Sponsor:

National Cancer Institute (NCI)

Code:

NCT01441089

Conditions

Prostate Cancer

Breast Cancer

Lung Cancer

Ovarian Cancer

Lymphoma

Eligibility Criteria

Sex: All

Age: 3+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Background:

\- Some genes may be associated with a greater chance of side effects during cancer treatment. These genes may also make certain treatments less effective. Researchers want to collect blood or cheek swab samples from people having cancer treatment to study these genes.

Objectives:

\- To obtain a blood or cheek swab sample to study genetic differences that may affect cancer treatment.

Eligibility:

\- Individuals with cancer who are being treated at the National Cancer Institute.

Design:

  • Participants will provide a blood sample for study.
  • Participants who have blood-based cancer, such as leukemia, will provide a cheek swab sample.
  • If the blood or cheek swab sample does not have enough genetic material for analysis, an additional sample may be collected.

Conditions

Prostate Cancer

Breast Cancer

Lung Cancer

Ovarian Cancer

Lymphoma

Study ID

NCT01441089

Start date

May 21, 2012

Status verified date

Jan 23, 2026

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 3+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:
  • Any individual currently enrolled in an NIH intramural research program clinical trials receiving treatment.
  • Ability of participant or Legally Authorized Representative (LAR) to understand and be willing to sign the informed consent document.
  • Age >= 3 years old

EXCLUSION CRITERIA:

-N/A

Study Design

Enrollment

1100 participants

Anticipated

Interventions and Outcome Measures

Arms

1/ Patients with cancer, other tumors, or possible genetic tumor

Patients enrolled on IRB approved NIH Intramural Research Program (IRP) therapeutic clinical trials

Primary outcome measure

  • Obtain and analyze the genomic DNA from patients with cancer, other tumors, or possible genetic tumor predisposition syndromes on a therapeutic clinical trial. [ Time Frame: duration of study ]

Central Contacts and Locations

Central contacts

Deneise C Francis, R.N.

(240) 858-3974deneise.francis@nih.gov

William D Figg, Pharm.D.

(240) 760-6179figgw@mail.nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Cancer Institute (NCI)

Last update posted

Aug 31, 2026

Last verified

Jan 23, 2026

Keywords

  • Pharmacogenetics
  • Pharmacokinetics
  • Pharmacodynamics
  • Clinical Outcome
  • Drug Metabolism and Transport
  • Natural History
  • Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by National Cancer Institute (NCI) on 2026-08-31.