RegadenosonDiagnostic Study of Rapid Regadenoson Stress Cardiovascular Magnetic Resonance (CMR) to Detect Coronary Artery Disease

Inclusion Criteria:

• Aged 18 years or older
• Scheduled for invasive coronary angiography

Exclusion Criteria:

• Inability to give informed consent
• Possible pregnancy (confirmed by urine test)
• Women who are breastfeeding
• Severe claustrophobia
• Inability to lie flat for 20-30 minutes (the anticipated amount of time to complete the MRI procedure)
• Individuals with cochlear implants
• Individuals with non-MRI compatible aneurysm clips
• Potential contraindications to regadenoson use due to:

Severe lung disease (active wheezing) Severe bradycardia (heart rate < 40 beats/min) Second- or third-degree atrioventricular heart block Sick sinus syndrome History of Long QT syndrome Severe hypotension (systolic BP < 80 mm Hg) Decompensated heart failure

• Contraindication to administration of Gadolinium (Gd) based contrast agents (GBCA):

Stage 4 or 5 chronic kidney disease (eGFR < 30 ml/min/1.73 m2) Known allergy to GBCA

Special Considerations:

- Although individuals who have an occupational history of welding, grinding, or other metal work will not be excluded from the study, they must undergo an orbital x-ray, to exclude any occult metal fragments, before they can participate in this study.