Recruiting

Antidepressants

Sponsor:

Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal

Code:

NCT01492621

Conditions

Major Depression

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Desvenlafaxine

Study Details

Brief summary:

Subjects with major depression will be evaluated and intensively characterized through questionnaires, computerized cognitive evaluation and laboratory investigations. Magnetic resonance imaging will be used to document baseline white matter structure. subjects will then receive desvenlafaxine which will be adjusted as clinically indicated. After 16 weeks the evaluations will be repeated.

Conditions

Major Depression

Study ID

NCT01492621

Start date

Nov, 2011

Status verified date

Dec, 2011

Completion date

Nov, 2013

Anticipated

Primary completion date

Sep, 2013

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Major depression
  • Age 18 to 55
  • Hamilton grater or equal to 20

Exclusion Criteria:

  • Major neurologic disorder
  • Major cardiovascular disorder
  • Unstable medical condition
  • Significant psychiatric co-morbidity
  • Current substance dependance
  • Pregnancy or lactation -Treatment resistance as defined by nonresponse to 2 or more antidepressant treatments (adequate dose and duration) -

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Interventions

Desvenlafaxine

Desvenlafaxine 50mg from week 1-8. At week 8 optional increase to 100mg if remission has not been attained.

Primary outcome measure

  • Anisotropy [ Time Frame: 16 weeks ]

Central Contacts and Locations

Central contacts

souad Lahlafi, BNurs

5142514000slahlafi.crfs@ssss.gouv.qc.ca

Louise Normandeau, Nurs

5142514000lnormandeau.hlhl@ssss.gouv.qc.ca

Locations

Centre de Recherche Fernand-Seguin

Recruiting

Montreal, Quebec, Canada, H1N3V2

Contacts

Souad Lahlafi, Bnurs

5142514000slahlafi.crfs@ssss.gouv.qc.ca

Louise Normandeau, Nurs

5142514000lnormandeau.hlhl@ssss.gouv.qc.ca

More Information

Sponsor

Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal

Last update posted

Dec 15, 2011

Last verified

Dec, 2011

Keywords

  • major depression
  • DTI
  • inflammatory markers
  • cognition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal on 2011-12-15.