Recruiting

Streptococcus

Sponsor:

University of Wisconsin, Madison

Code:

NCT01558804

Conditions

Streptococcal Pharyngitis

Eligibility Criteria

Sex: All

Age: 5 - 15

Healthy Volunteers: Not accepted

Interventions

Identifying group A strep carriers

Study Details

Brief summary:

The purpose of the research is to help understand why some children become carriers of strep and whether children who are carriers need to be treated with antibiotics.

Conditions

Streptococcal Pharyngitis

Study ID

NCT01558804

Start date

May 9, 2011

Status verified date

Feb, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 5 - 15

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Children ages 5-15 years
  • Positive rapid antigen detection test for group A streptococcus
  • Parent or legal guardian present and able to provide consent
  • Provider prescribes treatment with a beta lactam antibiotic
  • English speaking

Exclusion Criteria:

  • Unable to take beta lactam antibiotics
  • Other concurrent bacterial infection, i.e., pneumonia

Study Design

Enrollment

180 participants

Anticipated

Interventions and Outcome Measures

Arms

Rapid Strep Positive

Children will be eligible for this study if they are ages 5 to 15 years and have been diagnosed to have acute pharyngitis caused by GAS with a positive Rapid Antigen Detection Test (RADT).

Interventions

Identifying group A strep carriers

At study entry, at 14 days, and if follow up is positive, again in 14-21 days: Standard culture for GAS and analysis of mRNA.

Primary outcome measure

  • Identifying children who are pharyngeal carriers of Group A streptococcus [ Time Frame: 2 weeks ]

Central Contacts and Locations

Central contacts

Cherie Schommer, BA

608-262-2631schommer2@wisc.edu

Locations

UW Health Pediatric Clinics

Recruiting

Madison, Wisconsin, United States, 53717

Contacts

Bridget Johnson, BAN,RN,CCRC

608-264-1400bridget.johnson@pediatrics.wisc.edu

Principal Investigator:

Gregory DeMuri, MD

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

Feb 18, 2026

Last verified

Feb, 2026

Keywords

  • Streptococcus pyogenes
  • Streptococcus

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-02-18.