Recruiting

Lung Cancer

Sponsor:

University of Colorado, Denver

Code:

NCT01580982

Conditions

Lung Neoplasms

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.

Conditions

Lung Neoplasms

Study ID

NCT01580982

Start date

Jan 23, 2012

Status verified date

Feb, 2026

Completion date

Jan 30, 2029

Anticipated

Primary completion date

Jan 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies
2. Aged 18 years or older
3. Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.
4. Patients must have the ability to understand and willingness to sign an informed consent document.

Exclusion Criteria:

\-

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. [ Time Frame: To be determined upon funding ]

Central Contacts and Locations

Central contacts

Brandi Kubala

303-724-1657brandi.kubala@cuanschutz.edu

Locations

University of Colorado Cancer Center

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Brandi Kubala

303-724-1657brandi.kubala@cuanschutz.edu

Principal Investigator:

Erin Schenk, MD,Ph.D

More Information

Sponsor

University of Colorado, Denver

Last update posted

Feb 18, 2026

Last verified

Feb, 2026

Keywords

  • Oncogenes
  • Lung and Other Thoracic Cancers

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2026-02-18.