Recruiting

Nephrotic Syndrome

Sponsor:

The Hospital for Sick Children

Code:

NCT01605266

Conditions

Nephrotic Syndrome

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Study Details

Brief summary:

INSIGHT is a longitudinal study of childhood nephrotic syndrome to determine genetic, serologic and environmental factors contributing to nephrotic syndrome and disease progression.

Conditions

Nephrotic Syndrome

Study ID

NCT01605266

Start date

Jan, 2011

Status verified date

Oct, 2022

Completion date

Jan, 2032

Anticipated

Primary completion date

Jan, 2032

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. diagnosis of nephrotic syndrome
2. signed informed consent and assent appropriate for age
3. ages 6 months -18 years old and
4. ability to complete questionnaires

Exclusion Criteria:

1. congenital nephrotic syndrome (less than age 1)
2. syndromic disease with multiple organ involvement
3. inability to provide consent by primary care providers
4. conditions such as systemic lupus erythematous.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Nephrotic Syndrome

The cohort includes all children diagnosed with nephrotic syndrome between ages 1-18. Children and their caregiver must be willing to provide informed consent, complete questionnaires, and provide biospecimens of the child. Those with secondary causes of nephrotic syndrome and/or systemic disease are excluded.

Primary outcome measure

  • Relapse (number of relapses) [ Time Frame: Entire follow-up ]

Central Contacts and Locations

Central contacts

Rulan Parekh, MD

416-813-7654rulan.parekh@sickkids.ca

Locations

William Osler Health System, Brampton Civic Hospital and Peel Memorial Centre for Integrated Health and Wellness

Recruiting

Brampton, Ontario, Canada, L6R 3J7

Principal Investigator:

Rachel J Pearl, MD

Hamilton Health Sciences Corporation - McMaster University Medical Centre

Recruiting

Hamilton, Ontario, Canada, L8L 8E7

Principal Investigator:

Rahul Chanchlani, MD, MSc

Rouge Valley Health System, Rouge Valley Centenary

Recruiting

Scarborough, Ontario, Canada, M1E 4B9

Principal Investigator:

Hubert Wong, MD

The Hospital for Sick Children

Recruiting

Toronto, Ontario, Canada, M5G 1X8

Principal Investigator:

Rulan Parekh, MD

More Information

Sponsor

The Hospital for Sick Children

Last update posted

Oct 25, 2022

Last verified

Oct, 2022

Keywords

  • pediatric
  • kidney disease
  • minimal change disease
  • focal segmental glomerulosclerosis
  • nephrotic syndrome

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The Hospital for Sick Children on 2022-10-25.