Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT01643512

Conditions

Liver Disease

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors. NAFLD is often associated with the traits of the metabolic syndrome including diabetes, high cholesterol or elevated blood pressure. Currently, there are no accurate noninvasive means of evaluating NAFLD and its more serious form which includes inflammation that may lead to severe scarring in the liver. The goal of this study is to evaluate shared genetic factors that underlie NAFLD and features of the metabolic syndrome as determined by blood work and radiographic studies in a cohort of twins and first degree relatives.

Conditions

Liver Disease

Study ID

NCT01643512

Start date

Aug, 2011

Status verified date

May, 2021

Completion date

Aug, 2021

Anticipated

Primary completion date

Aug, 2021

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Subjects must be at least 18 years of age
2. The subject is willing and able to complete all procedures and observations specified in the protocol
3. The subject has been fully informed and has personally signed and dated the written Informed Consent/Assent and Health Insurance Portability and Accountability Act (HIPAA) provisions.

Exclusion Criteria:

1. The subject is a female who is pregnant or nursing.
2. Contraindications to MRI:

  • The subject has any contraindication to MR imaging, such as patients with pacemakers, metallic cardiac valves, magnetic material such as surgical clips, implanted electronic infusion pumps or other conditions that would preclude proximity to a strong magnetic field.
  • The subject has a history of extreme claustrophobia.
  • The subject cannot fit inside the MR scanner cavity

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Central Contacts and Locations

Central contacts

Archana Bhatt

619-471-3915abhatt@ucsd.edu

Locations

University of California, San Diego

Recruiting

San Diego, California, United States, 92103

Contacts

Archana R Bhatt

619-471-3915abhatt@ucsd.edu

More Information

Sponsor

University of California, San Diego

Last update posted

May 6, 2021

Last verified

May, 2021

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2021-05-06.