Recruiting

Observational Study

Sponsor:

Northwestern University

Code:

NCT01644903

Conditions

Liver Transplant

Hepatitis C

Chronic Kidney Disease

Acute Rejection

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study is being done to test blood, urine and tissue samples to see if this can help decide if CKD (Chronic Kidney Disease), AR (Acute Rejection) and HCV (Hepatitis C Virus) can be identified in its early stages. CKD damage to the kidneys, AR and HCV all lower the body's ability to function properly. Early detection of these conditions could assist with successful treatment and possibly lead to less repeat organ transplants.

Conditions

Liver Transplant

Hepatitis C

Chronic Kidney Disease

Acute Rejection

Study ID

NCT01644903

Start date

Apr, 2010

Status verified date

May, 2026

Completion date

Dec, 2031

Anticipated

Primary completion date

Dec, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Male and female recipients of all races, ≥18 years of age.
2. Patients undergoing primary or subsequent living or deceased donor liver transplantation.
3. Subject and/or guardian must be able to provide informed consent.
4. Subject and/or guardian must be able to comply with the study protocol.

Exclusion Criteria:

1\. Inability or unwillingness of a participant and/or guardian to provide informed consent.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Proteogenomic Biomarkers for CKD, AR and HCV [ Time Frame: At time of liver biopsy ]

Central Contacts and Locations

Central contacts

Misael Villegas, BA

misael.villegas@northwestern.edu

Locations

Northwestern Memorial Hospital

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Misael Villegas, BA

misael.villegas@northwestern.edu

Jairo Chavez, BA

jairo.chavez@northwestern.edu

More Information

Sponsor

Northwestern University

Last update posted

May 22, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-05-22.