Recruiting

Cognitive Control Training

Sponsor:

Boston University

Code:

NCT01694719

Conditions

Depression

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

Brief Behavioral Activation Treatment for Depression

Cognitive Control Training

Study Details

Brief summary:

The purpose of this study is to evaluate the potential effects of a cognitive training program when combined with a particular form of psychotherapy (behavioral activation therapy) for depression. Behavioral activation therapy targets changes in behavior as a method for improving a depressed individual's thoughts, feelings, and overall quality of life. This study is designed to test whether a computerized brain exercise called cognitive control training can enhance the effects of a 5-session behavioral activation therapy program. CCT has been shown to reduce depressive symptoms in two other studies, but it has not yet been combined with behavioral activation therapy. The investigators hypothesize that individuals assigned to the behavioral activation plus cognitive control training condition will demonstrate reduced depressive symptoms from pre to post treatment compared with those assigned to the behavioral activation plus computerized control condition. The investigators hypothesize that these gains will be maintained at one-month follow up.

Conditions

Depression

Study ID

NCT01694719

Start date

Sep, 2012

Status verified date

Sep, 2012

Completion date

Oct, 2013

Anticipated

Primary completion date

Oct, 2013

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adults ages 18-65
2. Primary psychiatric diagnosis of major depressive disorder
3. Ability to read and speak English sufficiently to complete study procedures
4. If taking antidepressant or anxiolytic medication, participants must be taking a stabilized dose for a minimum period of at least 8 weeks prior to entry into the study
5. Willingness and ability to comply with the requirements of the study protocol

Exclusion Criteria:

1. Lifetime history of bipolar disorder or psychotic disorder
2. Neurological disorder such as Parkinson's disease or traumatic brain injury
3. Alcohol or substance dependence within the past 6 months
4. Substantial suicide risk
5. Concurrent psychotherapy initiated within 2 months of baseline, or ongoing psychotherapy of any duration directed specifically toward treatment of the depression other than general supportive therapy
6. Current use of antipsychotics, stimulants, or modafinil

Study Design

Enrollment

26 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Behavioral Activation + Cognitive Control Training

Participants will receive 5 sessions of behavioral activation therapy concurrent with 4 sessions of cognitive control training, a computerized intervention which targets cognitive control processes such as working memory and attention.

active comparator: Behavioral Activation Therapy plus Control Task

Participants will receive 5 sessions of behavioral activation therapy and 4 sessions of a non-active, computerized control task.

Interventions

Brief Behavioral Activation Treatment for Depression

Cognitive Control Training

Primary outcome measure

  • Beck Depression Inventory [ Time Frame: undefined ]

Central Contacts and Locations

Central contacts

Samantha J Moshier, M.A.

617-358-4311smoshier@bu.edu

Michael W Otto, Ph.D.

617-353-9610mwotto@bu.edu

Locations

Boston University - Translational Research Program

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Samantha Moshier, M.A.

617-358-4311smoshier@bu.edu

More Information

Sponsor

Boston University

Last update posted

Sep 27, 2012

Last verified

Sep, 2012

Keywords

  • Depression
  • Major Depressive Disorder
  • Behavioral Activation
  • Cognitive Training

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Boston University on 2012-09-27.