Recruiting

Observational Study

Sponsor:

British Columbia Cancer Agency

Code:

NCT01719068

Conditions

Mesothelioma

Lung Cancer

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma. This is high risk population is at of respiratory system diseases as a result of their occupational exposures. Additionally, knowledge garnered from this study will allow us to develop other studies that will further our understanding of asbestos related lung cancer and mesothelioma.

Conditions

Mesothelioma

Lung Cancer

Study ID

NCT01719068

Start date

Oct, 2012

Status verified date

Oct, 2012

Completion date

Dec, 2014

Anticipated

Primary completion date

Oct, 2014

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Women or men age 50 to 79 years
  • history of exposure to asbestos at work and one or more of the following:

  • lung cancer risk ≥2% over 3 years or
  • asbestosis or pleural plaques on a chest x-ray or
  • abnormal auto-antibodies level using the EarlyCDT test
  • Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

Exclusion Criteria:

  • Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
  • Have been previously diagnosed with mesothelioma
  • Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended >6 months before registration into this study
  • Pregnancy
  • Unwilling to have a low dose CT scan of chest
  • Unwilling to sign a consent

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

Workers exposed to asbestos

Primary outcome measure

  • Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Sharon Gee

604-675-8089sgee@bccancer.bc.ca

Locations

British Columbia Cancer Agency

Recruiting

Vancouver, British Columbia, Canada, V5Z1L3

Contacts

Sharon Gee

604-675-8089sgee@bccancer.bc.ca

Principal Investigator:

Stephen Lam, MD

More Information

Sponsor

British Columbia Cancer Agency

Last update posted

Nov 1, 2012

Last verified

Oct, 2012

Keywords

  • Mesothelioma
  • Lung Cancer
  • Early Detection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by British Columbia Cancer Agency on 2012-11-01.