Recruiting

Stereotactic Radiosurgery

Sponsor:

Vanderbilt University Medical Center

Code:

NCT01734122

Conditions

Tremor

Essential Tremor

Parkinson Disease

Radiosurgery

Quality of Life

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Questionnaires / Observational Assessments

Study Details

Brief summary:

The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.

Conditions

Tremor

Essential Tremor

Parkinson Disease

Radiosurgery

Quality of Life

Study ID

NCT01734122

Start date

Feb 21, 2013

Status verified date

Sep, 2026

Completion date

Sep, 2029

Anticipated

Primary completion date

Sep, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Must be certified by a neurologist as having essential tremor or Parkinsonian tremor that is insufficiently controlled by medication alone.
  • Preference to receive radiation treatment for tremor treatment, rather than surgical DBS implantation or surgical thalamotomy
  • At least 18 years old

Exclusion Criteria:

  • Contraindications to cranial radiation (such as prior radiation to the thalamus)
  • Inability to have a MRI of the brain
  • Prior surgical thalamotomy treatment (but contralateral deep brain stimulator \[DBS\] is permitted)
  • Estimated life expectancy less than 1 year

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

Essential Tremor

Patients with severe, medication-refractory Essential Tremor

Parkinsonian Tremor

Patients with severe, medication-refractory, tremor-dominant Parkinsons

Interventions

Questionnaires / Observational Assessments

Includes QUEST, PDQ-39, FTM, and Neuropsych evaluation

Primary outcome measure

  • Tremor-related Quality of Life [ Time Frame: 1 year ]

Central Contacts and Locations

Locations

Vanderbilt University Medical Center

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Send Patient Referrals to Movement Disorder Coordinators

615-322-0141 or 615-936-0060

Vanderbilt University Radiation Oncology (nursing staff)

615-343-2624

Principal Investigator:

Austin N. Kirschner, MD, PhD

More Information

Sponsor

Vanderbilt University Medical Center

Last update posted

Sep 16, 2026

Last verified

Sep, 2026

Keywords

  • Stereotactic Radiosurgery
  • Essential Tremor
  • Parkinsonian Tremor
  • Quality of Life
  • Severity of Tremor

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-25. This information was provided to ClinicalTrials.gov by Vanderbilt University Medical Center on 2026-09-16. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.