Recruiting

Observational Study

Sponsor:

Arunark Kolipaka

Code:

NCT01757730

Conditions

Heart Failure

Liver Fibrosis

Cardiac Transplant Rejection

Aortic Aneurysms

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc. In this imaging technique a person is laid in an MR scanner and a paddle (plastic drum) is put on the area of interest to send sound vibration via a speaker placed outside the scan room which is connecting plastic drum via a plastic tube. These vibrations are scanned using MRI to estimate the stiffness of soft tissues such as liver, heart, kidneys, breast etc.

Conditions

Heart Failure

Liver Fibrosis

Cardiac Transplant Rejection

Aortic Aneurysms

Study ID

NCT01757730

Start date

Mar, 2012

Status verified date

Apr, 2025

Completion date

Mar 1, 2028

Anticipated

Primary completion date

Mar 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

Any participant 18 years or older and are MR safe.

Exclusion Criteria:

That study participants will be excluded if they have any unapproved metal in their bodies, or if the volunteers are pregnant or possible of becoming pregnant. Also if the participants are claustrophobic.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Altered Stiffness

Tissue stiffness will be evaluated in subjects those with disease conditions where stiffness changes from normal. These studies will be repeated for reproducibility.

Healthy Volunteers

Tissue stiffness will be evaluated in normal subjects to determine the normal values. These studies will be repeated for reproducibility.

Primary outcome measure

  • Stiffness of soft tissues [ Time Frame: Participants will be followed for the duration of hospital stay, ecah clinical visit after discharge for an expected average up to 1 year ]

Central Contacts and Locations

Central contacts

Arunark Kolipaka

614-366-0268arunark.kolipaka@osumc.edu

Kristin L Thompson, B.S.

614-366-5429Kristin.Thompson@osumc.edu

Locations

The Ohio State University Wexner Medical Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Kristin L Thompson, B.S.

614-366-5429Kristin.Thompson@osumc.edu

Principal Investigator:

Arunark Kolipaka, PhD

More Information

Sponsor

Arunark Kolipaka

Last update posted

Apr 6, 2025

Last verified

Apr, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Arunark Kolipaka on 2025-04-06.