Recruiting

Cytokine Response

Sponsor:

University of Manitoba

Code:

NCT01770457

Conditions

Septic Shock

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease.

The specific objective is to obtain sequential serum samples from patients with septic shock, examine a broad range of cytokine responses (TNF, IL-1, IL-6, MIF, LIF, HMGB1, etc) in a rigorous manner and correlate these responses to administration of antibiotics, resuscitative efforts and physiologic responses to illness (temp, HR, blood pressure, WBC, etc).

Conditions

Septic Shock

Study ID

NCT01770457

Start date

Apr, 2006

Status verified date

Jul, 2013

Completion date

Dec, 2014

Anticipated

Primary completion date

Feb, 2014

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult ICU patients: . 18 years admitted with septic shock
  • Receiving Vasopressors < 24 hrs

Exclusion Criteria:

  • Consent refused by patient or SDM
  • Received Vasopressors > 24hrs

Study Design

Enrollment

325 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Cytokine response in septic shock [ Time Frame: Hours 0, 3, 6, 12, 18, 24, 36, 48, 96 and day 7 ]

Central Contacts and Locations

Central contacts

Anand Kumar, MD

204-291-0372akumar61@yahoo.com

Wendy Janz, RN

204-787-1405wjanz@hsc.mb.ca

Locations

Health Sciences Centre, Winnipeg

Recruiting

Winnipeg, Manitoba, Canada, R3A 1R9

Contacts

Wendy Janz, RN

204-787-1405wjanz@hsc.mb.ca

Principal Investigator:

Anand Kumar, MD

More Information

Sponsor

University of Manitoba

Last update posted

Jul 25, 2013

Last verified

Jul, 2013

Keywords

  • ICU population

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Manitoba on 2013-07-25.