Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT01774539

Conditions

Fracture

Eligibility Criteria

Sex: All

Age: 8 - 12

Healthy Volunteers: Not accepted

Interventions

Diffusion MRI

Study Details

Brief summary:

Children who suffer fractures to the growth plates (physes) of their bones are at risk for premature growth arrest which can lead to long term complications. There is currently no technique to predict who is at risk of growth arrest following a physeal injury. The investigators aim to determine if diffusion MRI (an imaging method to analyze tissue properties) can effectively pick up differences between a healthy growth plate and an injured one. This would allow orthopaedics surgeons to predict which injuries are at a higher risk of growth arrest, so earlier interventions can be done in the orthopaedic clinic.

Conditions

Fracture

Study ID

NCT01774539

Start date

Nov, 2014

Status verified date

Jun, 2016

Completion date

Feb, 2017

Anticipated

Primary completion date

Feb, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 8 - 12

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Salter-Harris Type II, III, or IV fracture through the distal radius
  • Growth plates are open
  • Ages 8-12
  • Able to consent in English

Exclusion Criteria:

  • All fractures not sustained to distal radius
  • SH Type I or V fracture
  • Injury to contralateral limb
  • Previous injury to distal radius
  • Diseases known to alter bone healing or growth\]
  • Contraindications to undergoing an MRI scan

Study Design

Enrollment

10 participants

Anticipated

Interventions and Outcome Measures

Arms

Physeal Injury - Distal Radius

Patients who suffer a physeal fracture of the distal radius will be scanned and compared to their healthy contralateral limb.

Interventions

Diffusion MRI

Each subject will undergo one diffusion MRI scan to identify characteristics of their physes

Primary outcome measure

  • Tissue characterization of growth plate using diffusion MRI [ Time Frame: 4-6 weeks following injury ]

Central Contacts and Locations

Central contacts

Sameer Desai

604-875-2359sameer.desai@cw.bc.ca

Locations

British Columbia Children's Hospital

Recruiting

Vancouver, British Columbia, Canada, V6H 3V4

Contacts

Sameer Desai

604-875-2359sameer.desai@cw.bc.ca

Principal Investigator:

Firoz Miyanji, MD, FRCSC

More Information

Sponsor

University of British Columbia

Last update posted

Jun 13, 2016

Last verified

Jun, 2016

Keywords

  • Fracture
  • Physeal injury
  • Diffusion MRI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2016-06-13.