Recruiting

Observational Study

Sponsor:

National Institute of Dental and Craniofacial Research (NIDCR)

Code:

NCT01805869

Conditions

Stomatognatic

Tooth Diseases

Diseases

Tooth

Tooth Impaction

Eligibility Criteria

Sex: All

Age: 16 - 50

Healthy Volunteers: Accepted

Study Details

Brief summary:

Background:

\- The third molars (wisdom teeth) normally grow in during late adolescence or early adulthood. Many people need or choose to have these teeth removed with oral surgery. Normally, the removed teeth and tissue are thrown away as medical waste. However, oral health researchers want to collect the teeth and tissue for research. They also want to encourage dentists at the National Institutes of Health to improve their skills in oral surgery. This study will collect the teeth and tissue of people who need to have oral surgery to remove their wisdom teeth.

Objectives:

  • To provide continued dental skills training for dentists at the National Institutes of Health.
  • To collect teeth and tissue samples following wisdom tooth removal surgery.

Eligibility:

\- Individuals between 16 and 50 who need to have their wisdom teeth removed.

Design:

  • This study will involve a minimum of three visits. There will be a screening visit, a surgery visit, and at least one follow-up visit.
  • Participants will be screened with a physical exam and medical history. A full dental exam with x-rays will be given to evaluate the need for surgery.
  • At the second visit, participants will have oral surgery to remove their wisdom teeth. The teeth and tissue removed during the surgery will be collected for study.
  • Participants will receive drugs to control the pain after surgery. They will also be able to contact a dentist if there are any problems.
  • Between 7 and 21 days after surgery, participants will have a followup visit to check the healing. If they are having no problems, this will be the last visit. If there are any postsurgery issues, they will be scheduled for additional visits as needed.

Conditions

Stomatognatic

Tooth Diseases

Diseases

Tooth

Tooth Impaction

Study ID

NCT01805869

Start date

Jun 19, 2013

Status verified date

Aug 26, 2026

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 16 - 50

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:
  • Ages greater than or equal to 16-50 years
  • Clinical evidence of need for third molar extraction as determined by medical, dental, and radiographic evaluation by a NIDCR oral surgeon
  • Willing to allow for the collection of extracted waste tissue (e.g., teeth, alveolar bone, excessive gingival tissue) to be used for research
  • In good general health as defined by the American Society of Anesthesiologists (ASA) status I or II
  • Able to understand and sign an informed consent

EXCLUSION CRITERIA:

  • Pregnant or nursing women
  • Unable to have third molar extraction as determined by NIDCR surgeon/dentist, due to medical conditions (beyond ASA I or II), complexity of the surgery, or history that precludes safe outpatient conscious sedation. These clinical decisions will be based on the risks and benefits related to the surgery.

Study Design

Enrollment

3000 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy volunteers

Male or female ages 16-50

Primary outcome measure

  • data collection [ Time Frame: 16 years ]

Central Contacts and Locations

Central contacts

Sharon M Mitchell

(301) 496-4372sharon.mitchell@nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

More Information

Sponsor

National Institute of Dental and Craniofacial Research (NIDCR)

Last update posted

Sep 1, 2026

Last verified

Aug 26, 2026

Keywords

  • Third Molar
  • Specimen Acquisition
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Institute of Dental and Craniofacial Research (NIDCR) on 2026-09-01.