Recruiting

Lung Volume Recruitment

Sponsor:

Ottawa Hospital Research Institute

Code:

NCT01891071

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Lung volume recruitment

Study Details

Brief summary:

Multiple sclerosis is a neurological disease that can affect lung function and cough efficacy. This pilot study will examine whether the lung volume recruitment technique can slow down the decline in lung function and cough.

Conditions

Multiple Sclerosis

Study ID

NCT01891071

Start date

Jul, 2013

Status verified date

Mar, 2016

Completion date

Apr, 2017

Anticipated

Primary completion date

Apr, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • History of multiple sclerosis, diagnosed by a neurologist in accordance with the 2010 McDonald criteria

Exclusion Criteria:

  • Concomitant parenchymal pulmonary disease or pleural disease
  • Symptomatic cardiomyopathy
  • Unable to perform pulmonary function testing or lung volume recruitment, due to comprehension or cooperation issues, physical inability such as bulbar or cerebellar dysfunction
  • Contra-indication to pulmonary function testing or lung volume recruitment such as myocardial infarction, bleeding aortic aneurysm, intracranial hemorrhage within the previous month
  • Known susceptibility to pneumothorax or pneumomediastinum
  • Not competent to provide informed consent

Study Design

Enrollment

35 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Lung volume recruitment

Lung volume recruitment twice daily for 9 months

no intervention: Standard care

Standard care

Interventions

Lung volume recruitment

Inflation of the lungs to their maximal insufflation capacity by the consecutive delivery, by a manual resuscitator in this study, of volumes of air that are held with a closed glottis

Primary outcome measure

  • Rate of decline of FVC (forced vital capacity) [ Time Frame: up to 9 months ]

Central Contacts and Locations

Locations

The Ottawa Hospital

Recruiting

Ottawa, Ontario, Canada, K1H 8L6

Contacts

Doug A. McKim, MD

613-737-8899dmckim@ottawahospital.on.ca

Principal Investigator:

Doug A McKim, MD

Hôpital Charles-LeMoyne

Recruiting

Greenfield Park, Quebec, Canada, J4V2H1

Contacts

Nadim Srour, MD

450-466-5000nadim.srour@usherbrooke.ca

Principal Investigator:

Nadim Srour, MD

More Information

Sponsor

Ottawa Hospital Research Institute

Last update posted

Mar 31, 2016

Last verified

Mar, 2016

Keywords

  • Multiple sclerosis
  • Lung volume recruitment
  • Pulmonary function impairment
  • Cough impairment

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ottawa Hospital Research Institute on 2016-03-31.