Recruiting

Observational Study

Sponsor:

Laval University

Code:

NCT01909544

Conditions

Pulmonary Disease, Chronic Obstructive

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Interventions

Fatiguing exercise

Study Details

Brief summary:

The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

Conditions

Pulmonary Disease, Chronic Obstructive

Study ID

NCT01909544

Start date

Sep, 2011

Status verified date

Feb, 2014

Primary completion date

Jul, 2014

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
  • Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
  • Smoking history > 15 pack-years

Exclusion Criteria:

  • Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
  • Recent exacerbation (< 3 months)
  • Recent cancer (< 3 years)
  • Diabetes
  • Myopathy, neuromuscular or articular disease
  • Unstable cardiac disease
  • Absolute contraindications to exercise testing
  • Regular physical activity or exercise training program in the last 2 months
  • Physical activity score > 9 in the Voorips questionnaire
  • Thigh skinfold thickness > 15 mm
  • BMI > 30

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Oxygen

sham comparator: Room air

Interventions

Fatiguing exercise

All participants (patients and healthy subjects) will perform the exercise both under normoxic (FiO2 = 0.21) and hyperoxic conditions (FiO2 = 100%)

Primary outcome measure

  • Muscle deoxygenation [ Time Frame: 45 seconds post-exercise (knee-extension repetitions) ]
  • Muscle metabolism [ Time Frame: 45 seconds post-exercise (knee extension repetitions) ]

Central Contacts and Locations

Central contacts

Fernanda Ribeiro, PhD candidate

418-656-8711fernanda.ribeiro@criucpq.ulaval.ca

Locations

Institut universitaire de cardiologie et de pneumologie de Québec

Recruiting

Québec, Quebec, Canada, G1V 4G5

Principal Investigator:

François Maltais, MD

More Information

Sponsor

Laval University

Last update posted

Feb 7, 2014

Last verified

Feb, 2014

Keywords

  • Pulmonary Disease, Chronic Obstructive
  • Muscle fatigue
  • Energy metabolism
  • Muscle oxygenation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Laval University on 2014-02-07.