MIOXMIOX for Early Detection of Acute Kidney Injury After Cardiac Surgery

Inclusion Criteria:

1. Male or female scheduled for cardiac surgery including placement of Left or Right ventricular assist devices, requiring cardiopulmonary bypass
2. Age greater than or equal to 18 years

Exclusion Criteria:

1. Age less than 18 years
2. Inability to obtain Informed Consent from patient or representative
3. Prisoners or other institutionalized or vulnerable individuals.
4. Participation in an interventional clinical study within the previous 30 days.
5. History of previous renal transplantation
6. Stage 4 or 5 chronic kidney disease (estimated GFR< 30 mL/min/1.73m2)
7. Known or suspected ongoing pre-operative acute renal failure due to any cause, including pre-renal, intrinsic renal or post-renal (obstructive) etiologies (as evidenced by increasing serum creatinine or oliguria pre-operatively)
8. Already receiving dialysis, in imminent need of dialysis or considered highly likely to need dialysis in the immediate post-operative period for fluid management.
9. Any known or suspected renal ischemic or nephrotoxic insult (such as cardiac arrest, intravenous contrast procedure, etc) during the 48 hrs prior to surgery.
10. Known or suspected infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV) infection; hepatitis B virus (HBV) infection or other infectious hepatitis.
11. Pre-operative hematocrit < 25%, recent blood transfusions have been administered to maintain hematocrit > 25% or any other contraindication to obtaining the study specified blood samples.

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