Recruiting

Neuroplastic Change

Sponsor:

University of British Columbia

Code:

NCT01937910

Conditions

Stroke

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Interventions

TRAIT Task

Study Details

Brief summary:

The main goal of this research is to advance understanding of how stroke changes both the structure and function of the brain. The investigators will determine which is the key driver of recovery of arm function after stroke: changes in the structure of the brain or changes in how brain regions interact with one another.

Conditions

Stroke

Study ID

NCT01937910

Start date

Sep, 2014

Status verified date

Jan, 2017

Completion date

Sep, 2018

Anticipated

Primary completion date

Sep, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • individuals aged 40-75
  • movement-related deficits associated with a middle cerebral artery stroke
  • first time stroke affecting the corona radiata and/or internal capsule
  • Fugl-Meyer upper extremity motor score of at least 15 but not greater than 55.

Exclusion Criteria:

  • outside the age range of 40-75
  • show signs of dementia (score < 24 on the Montreal Cognitive Assessment)
  • have aphasia (score < 13 on the Frenchay Aphasia Screen)
  • history of head trauma, a major psychiatric diagnosis, neurodegenerative disorder or substance abuse;
  • taking any drugs (GABAergic, N-methyl-D-aspartate A-receptor (NMDA) antagonist) known to influence neuroplasticity;
  • report contraindications to MRI (see supporting documents)

Study Design

Enrollment

88 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Stroke Group

Participants in the stroke group will complete 10 training sessions of the TRAIT task.

active comparator: Matched Healthy Control Group

Participants in the Matched Healthy Control group will complete 10 sessions of the TRAIT task

Interventions

TRAIT Task

Increased paretic arm will be manipulated through the performance of a semi-immersive virtual reality-based intercept and release task called TRAIT (TRack And Intercept Task), which is performed in an interactive environment. TRAIT employs an open source Kinect sensor, which tracks 3-D joint movement. Participants are asked to control an on-screen icon using movements of their paretic arm to intercept a moving object as it emerges from the side of a computer screen. Once intercepted, they must accurately throw the object to hit a target. Participants move up through 10 levels of the game as their skill improves. Participants will complete 10 TRAIT training sessions in 4 weeks for a total of 10,000 experimental movements.

Primary outcome measure

  • Change in Myelin water fraction [ Time Frame: Baseline and 30 days post baseline ]

Central Contacts and Locations

Central contacts

Tamara Koren, MA

604-822-6886tamara.koren@ubc.ca

Lara Boyd, PhD; PT

604-827-3369lara.boyd@ubc.ca

Locations

University of British Columbia

Recruiting

Vancouver, British Columbia, Canada, V6T 1Z3

Principal Investigator:

Lara Boyd, PT; PhD

More Information

Sponsor

University of British Columbia

Last update posted

Jan 10, 2017

Last verified

Jan, 2017

Keywords

  • neuroplastic change
  • myelin

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2017-01-10.