Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT02009969

Conditions

Psychotic Disorders

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.

Conditions

Psychotic Disorders

Study ID

NCT02009969

Start date

Sep, 2013

Status verified date

Dec, 2015

Completion date

Jan, 2017

Anticipated

Primary completion date

Jan, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 12+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Must be admitted to the BC (British Columbia) Psychosis Program at UBC (University of British Columbia) Hospital
  • Must have clinically diagnosed psychosis (e.g. schizophrenia)
  • Must be fluent in English
  • Must not be contraindicated for MRI (i.e., must not be claustrophobic, have metal in the body, be pregnant, have BMI greater than or equal to 40, etc.)

Exclusion Criteria:

• None, other than those listed above

Study Design

Enrollment

40 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Abdominal distribution of visceral fat versus subcutaneous fat [ Time Frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge ]
  • Changes in total brain volume [ Time Frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge ]
  • Changes in grey matter volume in the brain [ Time Frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge ]
  • Changes in white matter volume in the brain [ Time Frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge ]
  • Changes in the volume of brain structures [ Time Frame: Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge ]

Central Contacts and Locations

Central contacts

Heidi N Boyda, Ph.D.

604-875-2000hnboyda@gmail.com

Delrae Fawcett, M.Sc.

604-875-2000delrae.fawcett@ubc.ca

Locations

BC Mental Health & Addictions Research Institute

Recruiting

Vancouver, British Columbia, Canada, V5Z 4H4

Contacts

Heidi N Boyda, Ph.D.

604-875-2000hnboyda@gmail.com

Delrae Fawcett, M.Sc.

604-875-2000delrae.fawcett@ubc.ca

Principal Investigator:

Alasdair M Barr, Ph.D.

More Information

Sponsor

University of British Columbia

Last update posted

Dec 14, 2015

Last verified

Dec, 2015

Keywords

  • Psychosis
  • Adverse effects
  • Symptom Severity
  • Magnetic Resonance Imaging

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2015-12-14.