Recruiting

Myocardial Contrast Echocardiography

Sponsor:

Cedars-Sinai Medical Center

Code:

NCT02014701

Conditions

STEMI

Eligibility Criteria

Sex: All

Age: 31 - 70+

Healthy Volunteers: Not accepted

Interventions

Echocardiogram

Study Details

Brief summary:

The goal of this study will be to assess the incremental benefit of myocardial contrast echocardiography for the assessment of regional wall motion abnormalities and infarct-related artery in patients presenting with their first NSTEMI.

Conditions

STEMI

Study ID

NCT02014701

Start date

Aug, 2012

Status verified date

Dec, 2013

Completion date

Mar, 2014

Anticipated

Primary completion date

Mar, 2014

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 31 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Patients presenting with NSTEMI who are scheduled to undergo elective cardiac catheterization and coronary angiography with primary PCI

Exclusion Criteria:

Inability to undergo a contrast echocardiogram Unwillingness to consent to a contrast echocardiogram

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

other: Echocardiogram

Patients presenting with NSTEMI who are scheduled to undergo elective cardiac catheterization and coronary angiography with primary PCI will be selected for participation in the study. The patients will undergo a clinically indicated resting non-contrast echocardiogram to assess LV function and regional wall motion. They will then undergo contrast echocardiography with bolus injection of Optison™ contrast to reassess LV ejection fraction, improve LV opacification and assess regional wall motion abnormalities. Finally, they will be given a continuous infusion of Optison™ and will have assessment of myocardial perfusion of each of the 17 myocardial segments using low mechanical index continuous imaging of the myocardium and blood pool.

Interventions

Echocardiogram

1. Contrast echocardiography with Optison for assessment of regional wall motion. This will be performed immediately following the resting echocardiogram by a sonographer specifically trained in myocardial contrast echocardiography.
2. Contrast echocardiogram with Optison for assessment of myocardial perfusion. This will be performed using a continuous infusion of Optison using low mechanical index power-modulation imaging of the myocardium and blood pool. Myocardial perfusion will be assessed offline using video intensity analysis software.

Primary outcome measure

  • Accuracy of determination of the infarct related artery as compared to the findings from clinically indicated coronary angiography [ Time Frame: Baseline: Immediately following resting echocardiogram at time of index STEMI and prior to cardiac cath. ]

Central Contacts and Locations

Locations

Cedars-Sinail Medical Center

Recruiting

Los Angeles, California, United States, 90048

Contacts

Swaminatha Gurudevan, MD

310-423-3846Swaminatha.Gurudevan@cshs.org

Tracey S Early, BS, MA

310-423-1231tracey.early@cshs.org

Principal Investigator:

Swaminatha Gurudevan, MD

More Information

Sponsor

Cedars-Sinai Medical Center

Last update posted

Dec 18, 2013

Last verified

Dec, 2013

Keywords

  • echocardiogram
  • regional wall motion abnormalities
  • myocardial contrast

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Cedars-Sinai Medical Center on 2013-12-18.