Recruiting

Optical Coherence Tomography

Sponsor:

Oregon Health and Science University

Code:

NCT02026128

Conditions

Uveitis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer (one one-thousandths) scale imaging of biological tissue. This allows excellent assessment of the white blood and inflammatory cells seen in uveitis, an inflammation of any or all parts of the uvea (iris, ciliary body, choroid).

Conditions

Uveitis

Study ID

NCT02026128

Start date

Mar, 2012

Status verified date

Feb, 2024

Completion date

Dec, 2025

Anticipated

Primary completion date

Dec, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 18 years of age and older
  • With one or more of the following clinical features:

1. >1+ AC cells;
2. >1+ vitreous haze;
3. presence of vitreous cells;
4. presence of blood in anterior chamber;
5. presence of blood in vitreous;
6. presence of aqueous or vitreous pigment.
  • In one of the following diagnostic categories as determined by a uveitis specialists:

1. uveitis due to ankylosing spondylitis (positive HLA B27 genotype);
2. uveitis due to sarcoidosis;
3. uveitis of any additional type;
4. uveitis masquerade such as pigment dispersion syndrome or Schaffer's sign;
5. hyphema due to trauma or other causes;
6. vitreous hemorrhage;
7. retinal tear.

Exclusion Criteria:

  • Inability to give informed consent;
  • Inability to maintain stable fixation for OCT imaging.

Study Design

Enrollment

75 participants

Anticipated

Interventions and Outcome Measures

Arms

Active Uveitis

Physician-confirmed diagnosis of uveitis of any origin.

Primary outcome measure

  • Number of anterior chamber cells [ Time Frame: 1 month ]
  • Number of keratic precipitates (KP) [ Time Frame: 1 month ]
  • Number of vitreous cells [ Time Frame: 1 month ]
  • Degree of anterior chamber flare [ Time Frame: 1 month ]

Central Contacts and Locations

Central contacts

Locations

Oregon Health & Science University

Recruiting

Portland, Oregon, United States, 97239

Contacts

More Information

Sponsor

Oregon Health and Science University

Last update posted

Feb 12, 2024

Last verified

Feb, 2024

Keywords

  • Uveitis
  • Inflammation
  • OCT
  • Grading

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2024-02-12.