Recruiting

Observational Study

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT02087852

Conditions

Renal Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

salvia for germline DNA

the Kidney Cancer Questionnaire

Family History Questionnaire (when applicable)

Blood draw

Epidemiologic Questionnaire

Study Details

Brief summary:

This registry will help us develop better methods of:

  • Preventing these cancers
  • Diagnosing these cancers
  • Treating these cancers

Conditions

Renal Cancer

Study ID

NCT02087852

Start date

Mar, 2014

Status verified date

Apr, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Mar, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

Kidney Cancer Case Cohort:

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must have a diagnosis or suspicion of kidney cancer

Family Member Cohort:

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must be a blood relative of the proband. Family members of probands including mother, father, sisters, brothers, half-sisters, half-brothers, daughters, sons, grandmothers, grandfathers, as well as aunts and uncles are eligible. These individuals need not have kidney cancer, as they will be used for segregation analysis of suspected variants found in the proband; requesting DNA from relatives is required.

Control Cohort:

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must not have a personal history of cancer, with the exception of nonmelanoma skin cancer, AND
  • Must not be a blood relative of any cases or controls enrolled in this study

Exclusion Criteria:

  • Patients who, in the opinion of the primary MSKCC clinician or the investigator, have a condition that precludes their ability to provide an informed consent

Study Design

Enrollment

750 participants

Anticipated

Interventions and Outcome Measures

Arms

kidney cancer patients receiving care at MSKCC

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire and complete the Epidemiologic Questionnaire (when applicable,), and providing a blood sample and saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

relatives of patients with kidney cancer

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire (when applicable,), and providing a saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

healthy controls who are unrelated & do not have hx of cancer

Participation will consist of completing the Kidney Cancer Questionnaire Family History Questionnaire (when applicable,), and providing a saliva sample for germline DNA. In cases where tissue samples from surgically derived tumor specimens are obtained these will used to determine genetic alterations related to cancer predisposition or pathogenicity.

high risk

Participation will consist of completing the Epidemiologic Questionnaire, Family History Questionnaire (if + FH), provide saliva and blood sample , referral for screening evaluation

Interventions

salvia for germline DNA

the Kidney Cancer Questionnaire

Patients will complete the appropriate surveys on either paper or on the computer/iPad in the office using REDCap software. If patients are unable to complete their questionnaires at the time of their in-office visit, a link to the questionnaires in REDCap will be emailed to them. The survey data that is collected in REDCap will be stored in REDCap. Clinic staff may also call patients to remind patients to complete questionnaires.

Family History Questionnaire (when applicable)

Patients will complete the appropriate surveys on either paper or on the computer/iPad in the office using REDCap software. If patients are unable to complete their questionnaires at the time of their in-office visit, a link to the questionnaires in REDCap will be emailed to them. The survey data that is collected in REDCap will be stored in REDCap. Clinic staff may also call patients to remind patients to complete questionnaires.

Blood draw

Epidemiologic Questionnaire

Patients will complete the appropriate surveys on either paper or on the computer/iPad in the office using REDCap software. If patients are unable to complete their questionnaires at the time of their in-office visit, a link to the questionnaires in REDCap will be emailed to them. The survey data that is collected in REDCap will be stored in REDCap. Clinic staff may also call patients to remind patients to complete questionnaires.

Primary outcome measure

  • establish a kidney cancer registry [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Jonathan Coleman, MD

646-422-4432

Kenneth Offit, MD

646-888-4050

Locations

Memorial Sloan Kettering at Basking Ridge (Consent and Follow-up)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Jonathan Coleman, MD

646-422-4432

Memorial Sloan Kettering Monmouth (Consent and Follow up)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Jonathan Coleman, MD

646-422-4432

Memorial Sloan Kettering Bergen (Consent and Follow up )

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Jonathan Coleman, MD

646-422-4432

Memorial Sloan Kettering Commack (Consent and Follow-up)

Recruiting

Commack, New York, United States, 11725

Contacts

Jonathan Coleman, MD

646-422-4432

Memorial Sloan Kettering Westchester (Consent and Follow up)

Recruiting

Harrison, New York, United States, 10604

Contacts

Jonathan Coleman, MD

646-422-4432

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

Recruiting

New York, New York, United States, 10065

Contacts

Jonathan Coleman, MD

646-422-4432

Kenneth Offit, MD

646-888-4050

Principal Investigator:

Jonathan Coleman, MD

Memorial Sloan Kettering Nassau (Consent and Follow-Up)

Recruiting

Uniondale, New York, United States, 11553

Contacts

Jonathan Coleman, MD

646-422-4432

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Apr 9, 2026

Last verified

Apr, 2026

Keywords

  • Questionnaire
  • DNA
  • saliva
  • kidney cancer
  • 13-218
  • high risk

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-04-09.