Recruiting

Metabolic Biomarkers

Sponsor:

University of Texas Southwestern Medical Center

Code:

NCT02095808

Conditions

Lung Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Imaging Biomarkers

Study Details

Brief summary:

The purpose of this research study is to develop a method of using magnetic resonance imaging (MRI) to evaluate lung tumors and other thoracic malignancies. An MRI is a scanning device that uses magnets to make images (pictures) of the body. This study is being done to determine what series of reactions (metabolic pathways) pulmonary nodules use as they burn sugar as fuel for growth. The manner in which the tumor burns (metabolizes) sugar for fuel is being investigated by using a natural, slightly modified, sugar solution (13C-glucose) and studying a small sample of the tumor once it is removed at the time of surgery.

Conditions

Lung Cancer

Study ID

NCT02095808

Start date

Mar 20, 2013

Status verified date

Apr, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Patients must have known or probable malignant lesions requiring surgical biopsy or excision.
2. Subjects of all races and ethnic origins over 18 years of age.

Exclusion Criteria:

1. Not a surgical candidate.
2. Poorly controlled diabetes.

Study Design

Enrollment

200 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Surgery

The 13C-glucose solution will be given intravenously. It will be started at about the same time as the start of surgery, according to the study guidelines.

The 13C-glucose IV solution will be stopped once the surgeon has removed the tumor tissue.

Interventions

Imaging Biomarkers

Want to see if using 13C-glucose helps in detecting cancer and deciding on a treatment plan.

Primary outcome measure

  • DCE-MRI [ Time Frame: One time - within 5 days of the scheduled surgery ]

Central Contacts and Locations

Central contacts

Ebele Mbanugo, Ed.D, CCRP

214-648-7097ebele.mbanugo@utsouthwestern.edu

Locations

University of Texas Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75390

Contacts

Ebele Mbanugo, Ed.D, CCRP

214-648-7097ebele.mbanugo@utsouthwestern.edu

More Information

Sponsor

University of Texas Southwestern Medical Center

Last update posted

May 1, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Texas Southwestern Medical Center on 2026-05-01.