Recruiting

Observational Study

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT02099734

Conditions

Germ Cell Tumor

Testicular Tumor

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Questionnaires

sample of blood or saliva

Study Details

Brief summary:

This study is being done to create a registry to help us learn more about germ cell tumors (GCT) and other testicular tumors. The registry will include people with these tumors and also relatives and unrelated people without these tumors. This study will help us learn more about the prevention, diagnosis, treatment and outcome of these tumors. Studying relatives of patients and people unrelated to patients with GCT and other testicular tumors will help us understand why some people get these tumors and why some people don't.

Conditions

Germ Cell Tumor

Testicular Tumor

Study ID

NCT02099734

Start date

Jan, 2014

Status verified date

Feb, 2026

Completion date

Jan, 2028

Anticipated

Primary completion date

Jan, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

Case Cohort

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must have a diagnosis or suspicion of germ cell tumor and/or a testicular mass

Family Member Cohort

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must be a blood relative of the proband. Family members of probands are eligible. These individuals need not have a diagnosis of GCT-TT, as they will be used for segregation analysis of suspected variants found in the proband.

Control Cohort

  • Must be ≥ 18 years of age AND
  • Must be an English-speaker AND
  • Must not have a personal history of cancer, with the exception of non-melanoma skin cancer, AND
  • Must not have a family history of germ cell tumor or testicular tumor AND
  • Must not be a blood relative of controls enrolled in this study

Exclusion Criteria:

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

A: suspicion of germ cell tumor and/or a testicular mass

patients with testicular GCTs and non-GCT testicular tumors, extragonadal male GCTs, and female GCTs,

B: family members of Group A

relatives of patients with GCTs or testicular tumors

C: healthy controls unrelated to Group A or B

healthy controls who are unrelated to Groups A or B and do not have a personal history of cancer nor a family history of GCT or non-GCT testicular tumors

Interventions

Questionnaires

sample of blood or saliva

A sample of blood or saliva will be obtained for DNA extraction. Approximately 2-4 tubes of blood will be collected or one tablespoon of saliva. If a participant has already provided a DNA sample for another MSKCC IRB approved protocol, they may not need to provide an additional sample.

Primary outcome measure

  • creation of a Germ Cell Tumor and testicular tumor registry [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Darren Feldman, MD

646-422-4491

Joel Sheinfeld, MD

646-422-4311

Locations

Memorial Sloan Kettering Basking Ridge

Recruiting

Basking Ridge, New Jersey, United States

Contacts

Darren Feldman, MD

646-422-4491

Memorial Sloan Kettering Monmouth

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Darren Feldman, MD

646-422-4491

Memorial Sloan Kettering Bergen

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Darren Feldman, MD

646-422-4491

Memorial Sloan Kettering Commack

Recruiting

Commack, New York, United States, 11725

Contacts

Darren Feldman, MD

646-422-4491

Memorial Sloan Kettering Westchester

Recruiting

Harrison, New York, United States, 10604

Contacts

Darren Feldman, MD

646-422-4491

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Darren Feldman, MD

646-422-4491

Joel Sheinfeld, MD

646-422-4311

Principal Investigator:

Darren Feldman, MD

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Feb 4, 2026

Last verified

Feb, 2026

Keywords

  • 14-016

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-02-04.