Recruiting

Observational Study

Sponsor:

Centre hospitalier de l'Université de Montréal (CHUM)

Code:

NCT02100449

Conditions

Atelectasis

Pneumonia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Lung ultrasound and Doppler (Day 0)

Lung ultrasound and Doppler (Day 0)

Study Details

Brief summary:

In infectious lung consolidations, the inhibition of hypoxic pulmonary vasoconstriction (HPV) results in a higher regional acceleration time (RAcT) compared to the RAcT measured in atelectatic consolidations.

Conditions

Atelectasis

Pneumonia

Study ID

NCT02100449

Start date

Jun 1, 2014

Status verified date

Feb, 2024

Completion date

Nov 1, 2024

Anticipated

Primary completion date

Nov 1, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Under mechanical ventilation and presenting one or more consolidations on chest radiography or CT scan

Exclusion Criteria:

  • Participation to another study
  • Poor echogenicity (morbid obesity, multiple thoracic dressings)
  • Contra-indications to superior limbs or torso mobilization
  • Contra-indications to bronchoscopy
  • Antibiotics initiated more than 24 hours but less than 72 hours before inclusion or changes in the antibiotic regimen in the last 72 hours.

Study Design

Enrollment

64 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

other: Lung ultrasound and Doppler, pneumonia

In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed in patients with high clinical suspicion of pneumonia on Day 0. A bronchoalveolar lavage will also be performed on Day 0.

other: Lung ultrasound and Doppler, atelectasis

Patients without clinically active pulmonary disease but presenting a consolidation of suspected atelectatic nature. Fever, hypothermia, leucocytosis and leucopenia will not be present. Tracheal secretions will remain unchanged. There will be no deterioration of oxygenation. In this group, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0.

Interventions

Lung ultrasound and Doppler (Day 0)

In patients presenting a consolidation of suspected atelectatic nature, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0.

Lung ultrasound and Doppler (Day 0)

In patients presenting a consolidation of suspected infectious nature, a lung ultrasound examination using pulsed-wave Doppler will be performed on Day 0. A bronchoalveolar lavage will also be performed on Day 0.

Primary outcome measure

  • RAcT in lung consolidations [ Time Frame: During lung ultrasound examination - Day 0 ]

Central Contacts and Locations

Central contacts

Martin Girard, MD, FRCPC

514-890-8000martin.girard@umontreal.ca

Locations

Centre Hospitalier de l'Université de Montréal (CHUM)

Recruiting

Montreal, Quebec, Canada, H2X 3E4

Contacts

Martin Girard, MD, FRCPC

514-890-8000martin.girard@umontreal.ca

More Information

Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Last update posted

Feb 8, 2024

Last verified

Feb, 2024

Keywords

  • Atelectasis
  • Pneumonia
  • Lung ultrasound
  • Doppler

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM) on 2024-02-08.