Recruiting

Behavioral Tasks

Sponsor:

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Code:

NCT02108054

Conditions

Alcohol Dependence

Alcohol Drinking

Alcoholism

Alcohol Use Disorder

Addiction

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

7T MRI

Study Details

Brief summary:

Background:

\- Scientists know that alcohol use disorders affect brain structure. They want to know more about the effects of alcohol use disorders on a person s behavior. They want to develop tasks that can be done inside a scanner that can help them better understand these effects in later studies.

Objective:

\- To develop tasks that investigate a person s behavior that can be used in later studies.

Eligibility:

  • Inpatient participants of another study. They must be physically healthy right-handed adults 18-60 years old.
  • Healthy right-handed volunteers 18-65 years old.

Design:

  • Participants will be screened with medical history and physical exam. They will have an EKG to record heart activity. They will give blood and urine samples and have a psychiatric interview.
  • Participants will have between one and three visits.
  • Participants will be asked about their alcohol drinking to see if they have an alcohol use disorder.
  • Participants will complete one of three simple computerized tasks either inside the magnetic resonance imagining (MRI) scanner or outside of it.
  • The MRI scanner takes pictures of the brain. The scanner is a metal cylinder. Participants lie on a table that can slide in and out of the cylinder. They will be in the scanner for about 60 minutes. They may have to lie still for up to 20 minutes. The scanner makes loud knocking noises, but they will get earplugs.

Conditions

Alcohol Dependence

Alcohol Drinking

Alcoholism

Alcohol Use Disorder

Addiction

Study ID

NCT02108054

Start date

May 28, 2014

Status verified date

May 28, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

  • INCLUSION CRITERIA:
  • between 18-65 years of age. The PI or designated AI will determine if any of the exclusion criteria listed below applies\*.

EXCLUSION CRITERIA:

  • Are not cleared on a neuromotor examination
  • Are currently receiving psychotropic medication
  • Inpatients only: Currently experiencing symptoms of withdrawal from alcohol (As determined by the most recent measurement within the

past 30 days CIWA score > 8).

-MRI Exclusion Criteria:

  • Presence of ferromagnetic objects in the body including implanted pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent eye liner or small metallic fragments in the eye that welders and other metal workers may have;
  • Are pregnant, as determined by a negative pregnancy test
  • Left handed
  • Claustrophobia.

  • To minimize discomfort and undue burden on the participants, unless available from phone screening, pre-screening, or other NIAAA studies such as 14-AA-0080, 14-AA-0181, we collect the above information as part of this study.

Study Design

Enrollment

400 participants

Anticipated

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: 1

People with alcohol use disorder

experimental: 2

People without alcohol use disorder

Interventions

7T MRI

Modifying, refining, and verifying the feasibility and applicability of tasks for functional magnetic resonance imaging (fMRI) to measure intended concomitant brain activation

Primary outcome measure

  • outcome is to develop and examine tasks that reliably measure specific cognitive, motivational and decision-making behaviors [ Time Frame: ONGOING ]

Central Contacts and Locations

Central contacts

Beth A Lee, R.N.

(301) 451-6964beth.lee@nih.gov

Paule V Joseph, C.R.N.P.

(301) 827-5234paule.joseph@nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222ccopr@nih.gov

More Information

Sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Last update posted

Jun 30, 2026

Last verified

May 28, 2026

Keywords

  • fMRI
  • Alcoholism
  • Phenotype
  • Imaging
  • EEG
  • Psychophysiology
  • Near Infrared

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by National Institute on Alcohol Abuse and Alcoholism (NIAAA) on 2026-06-30.