Recruiting

Observational Study

Sponsor:

Oregon Health and Science University

Code:

NCT02109471

Conditions

Corneal Opacities (Scar and Stromal Dystrophy)

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.

Conditions

Corneal Opacities (Scar and Stromal Dystrophy)

Study ID

NCT02109471

Start date

Jun, 2011

Status verified date

Feb, 2024

Completion date

Dec, 2025

Anticipated

Primary completion date

Dec, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

• Adult (18 \& older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy)

Exclusion Criteria:

  • Inability to give informed consent.
  • Inability to maintain stable fixation for OCT imaging.
  • Inability to commit to required visits to complete the study.

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

corneal opacities

Primary outcome measure

  • Identification of suitable subjects [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Humberto Martinez, COT

503-494-7712martinhu@ohsu.edu

Denzil Romfh, OD

503-494-4351romfhd@ohsu.edu

Locations

Humberto Martinez

Recruiting

Portland, Oregon, United States, 97239

Contacts

Humberto Martinez, COT

503-494-7712martinhu@ohsu.edu

Denzil Romfh, OD

503-494-4351romfhd@ohsu.edu

Principal Investigator:

David Huang, MD, PhD

More Information

Sponsor

Oregon Health and Science University

Last update posted

Feb 12, 2024

Last verified

Feb, 2024

Keywords

  • corneal opacities
  • Optical coherence tomography

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Oregon Health and Science University on 2024-02-12.