Recruiting

Exercise & 5-HTP

Sponsor:

Benedictine University

Code:

NCT02187341

Conditions

Plasma Cortisol

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Accepted

Interventions

5-HTP

Placebo

Study Details

Brief summary:

It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.

Conditions

Plasma Cortisol

Study ID

NCT02187341

Start date

Jun, 2014

Status verified date

Jul, 2014

Completion date

Dec, 2015

Anticipated

Primary completion date

Dec, 2015

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy men and women, not taking medication known to alter glucocorticoid metabolism

Exclusion Criteria:

  • Diabetes
  • Obesity
  • Hypertension
  • Coronary artery disease
  • Psychiatric disorders
  • Any disease preventing them from participating in intense exercise
  • Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded

Study Design

Enrollment

12 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Interventions and Outcome Measures

Arms

experimental: 5-HTP

200 mg 5-HTP capsule will be ingested 2h prior to reporting to the laboratory.

placebo comparator: Placebo

For these visit subjects will ingest placebo (Sugar pill) capsule 2 hours before reporting to the laboratory.

Interventions

5-HTP

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Placebo

Volunteers participate in two visits at least 5 days apart . The day of their visit they ingest (2 hours before reporting to the laboratory) either a capsule containing 200 mg of 5-HTP or a capsule containing placebo (sugar pill). The order of the visits is randomized

Primary outcome measure

  • Change in plasma cortisol from baseline to 20 minutes post [ Time Frame: baseline, 20 min ]

Central Contacts and Locations

Central contacts

Pedro Del Corral, PhD-MD

630 8296575pdelcorral@ben.edu

Locations

Benedictine University

Recruiting

Lisle, Illinois, United States, 60532

Principal Investigator:

Pedro Del Corral, PhD-MD

More Information

Sponsor

Benedictine University

Last update posted

Jul 11, 2014

Last verified

Jul, 2014

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Benedictine University on 2014-07-11.