Recruiting
Phase 1
Phase 2

Hyperpolarized Xenon Gas

Sponsor:

Children's Hospital Medical Center, Cincinnati

Code:

NCT02272049

Conditions

Respiratory Disorders

Eligibility Criteria

Sex: All

Age: 6+

Healthy Volunteers: Accepted

Interventions

Hyperpolarized 129 Xenon

Study Details

Brief summary:

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Conditions

Respiratory Disorders

Study ID

NCT02272049

Start date

Dec, 2014

Status verified date

Feb, 2026

Completion date

Aug 31, 2029

Anticipated

Primary completion date

Dec 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 6+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Ages 6 and up
  • Participant must be able to hold breath for up to 16 seconds

Exclusion Criteria:

  • History of heart defect
  • Pregnancy or positive pregnancy test
  • History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
  • Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
  • Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
  • Participant is claustrophobic and unable to tolerate the imaging.
  • Standard MRI exclusions (metal, implants)

Study Design

Enrollment

300 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Hyperpolarized 129 Xenon

Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI (less for children) to optimize acquisition of images for children and adults vs. proton MR imaging

Interventions

Hyperpolarized 129 Xenon

During the scans, subject will inhale hyperpolarized Xenon gas for up to 16 seconds per scan, for up to 4 separate MR scans

Primary outcome measure

  • Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI [ Time Frame: Day 1 ]

Central Contacts and Locations

Central contacts

Carrie Stevens, BS

513-636-9973Carrie.Stevens@cchmc.org

Kelly Thornton, BS

513-636-0604Kelly.Thornton@cchmc.org

Locations

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Principal Investigator:

Jason C. Woods, PhD

More Information

Sponsor

Children's Hospital Medical Center, Cincinnati

Last update posted

Feb 17, 2026

Last verified

Feb, 2026

Keywords

  • Respiratory

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati on 2026-02-17.