Recruiting

Genetic Mutations

Sponsor:

Jonsson Comprehensive Cancer Center

Code:

NCT02280161

Conditions

Malignant Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

cytology specimen collection procedure

Study Details

Brief summary:

This research trial studies germ-line mutations in blood and saliva samples from patients with cancer. Studying samples of blood and saliva from patients with cancer in the laboratory may help doctors learn more about how inherited genetic mutations can affect cancer predisposition (an inherited increase in the risk of developing cancer), their impact on treatment response, and their role in cancer development.

Conditions

Malignant Neoplasm

Study ID

NCT02280161

Start date

Sep 16, 2014

Status verified date

Nov, 2025

Completion date

Sep 16, 2027

Anticipated

Primary completion date

Sep 16, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Pathologically or clinical confirmed tissue diagnosis of a cancer
  • Ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

  • Patients will be excluded if their cancer cannot be confirmed
  • Refusal to sign the informed consent

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Arms

Ancillary-Correlative (germ-line mutation analysis)

Patients undergo collection of blood and saliva samples 1-3 times at the discretion of the investigator for germ-line mutation analysis.

Interventions

cytology specimen collection procedure

Correlative studies

Primary outcome measure

  • Prevalence of germ-line variants [ Time Frame: Up to 5 years ]
  • Overall genotype frequencies [ Time Frame: Up to 5 years ]
  • Response to treatment [ Time Frame: Up to 5 years ]
  • Cancer development [ Time Frame: Up to 5 years ]

Central Contacts and Locations

Locations

Jonsson Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90095

Contacts

Joanne B. Weidhaas

310-825-9775jweidhaas@mednet.ucla.edu

Principal Investigator:

Joanne B. Weidhaas

More Information

Sponsor

Jonsson Comprehensive Cancer Center

Last update posted

Nov 10, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Jonsson Comprehensive Cancer Center on 2025-11-10.