Recruiting

Neuromodulation

Sponsor:

UCLA

Code:

NCT02331979

Conditions

Spinal Cord Injury

Eligibility Criteria

Sex: Male

Age: 18 - 45

Healthy Volunteers: Not accepted

Interventions

Electromagnetic Neuromodulation

Study Details

Brief summary:

This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.

Conditions

Spinal Cord Injury

Study ID

NCT02331979

Start date

Sep, 2015

Status verified date

Feb, 2026

Completion date

Jan 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 18 - 45

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Male 18-45 years;
2. At least 1 year post-injury;
3. Non-progressive SCI at C2-T8 (non-conus injury);
4. Motor Complete ASIA (A or B);
5. Neurogenic bladder requiring clean intermittent straight catheterization;
6. Able to attend twice weekly testing sessions for 6 months.
7. Have intact lower extremity anatomy and able to use lower extremity for assistive standing and stepping.

Exclusion Criteria:

1. History of autonomic dysreflexia;
2. Ventilator dependency;
3. Musculoskeletal dysfunction, unhealed fracture, pressure ulcer, active infection;
4. Clinically significant depression or ongoing drug abuse;
5. Received botox injection, or bladder surgery (suprapubic access, Brindley procedure, etc.); 6. Prostatic hypertrophy or bladder outlet disorder;

7\. Cardiopulmonary disease that precludes lower extremity training or rehabilitation.

Study Design

Enrollment

24 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Stimulation of Non-Naive

Evaluate neuromodulation in 6 subjects with prior motor training.

experimental: Stimulation of Naive

Evaluate neuromodulation in 6 naive subjects.

experimental: Stimulation

Apply parameters discovered in Arm 1 and Arm 2 to evaluate neuromodulation in 12 naive subjects.

Interventions

Electromagnetic Neuromodulation

Electromagnetic stimulation to neuromodulate the spinal cord in the context of spinal cord injury.

Primary outcome measure

  • Urine flow and volume [ Time Frame: Months 1-48 ]

Central Contacts and Locations

Central contacts

Daniel Lu, MD PhD

310-825-4321dclu@mednet.ucla.edu

Locations

University of California, Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Daniel C Lu, MD PhD

310-267-2975dclu@mednet.ucla.edu

More Information

Sponsor

University of California, Los Angeles

Last update posted

Feb 13, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-02-13.