Recruiting

Chronic Kidney Disease

Sponsor:

University of Delaware

Code:

NCT02364648

Conditions

Chronic Kidney Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MitoQ

Placebo

Study Details

Brief summary:

The purpose of this study is to examine the effect of mitochondria derived oxidative stress on vascular function in patients with moderate to severe Chronic Kidney Disease.

Conditions

Chronic Kidney Disease

Study ID

NCT02364648

Start date

Jul 1, 2017

Status verified date

Apr, 2019

Completion date

Sep 30, 2019

Anticipated

Primary completion date

Aug 30, 2019

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Stage 3 - 5 Chronic Kidney Disease

Exclusion Criteria:

  • History of cardiovascular disease;
  • Current pregnancy;
  • Uncontrolled hypertension;
  • Uncontrolled hyperlipidemia;
  • Current hormone replacement therapy;
  • Current use of tobacco products;
  • Elevated liver enzymes;
  • Current autoimmune disease;
  • Daily use of of antioxidants >300mg

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: MitoQ

4 week 20mg oral daily dose of MitoQ

placebo comparator: Placebo

4 week 20mg oral daily placebo

Interventions

MitoQ

Mitochondria targeted antioxidant

Placebo

Placebo

Primary outcome measure

  • Microvascular Function, assessed by laser Doppler flowmetry coupled with microdialysis [ Time Frame: Change from baseline at 4 weeks ]

Central Contacts and Locations

Central contacts

Danielle L Kirkman, PhD

302 831 4659dkirkman@udel.edu

David G Edwards, PhD

dge@udel.edu

Locations

Department of Kinesiology and Applied Physiology, University of Delaware

Recruiting

Newark, Delaware, United States, 19713

Contacts

David Edwards, PhD

dge@udel.edu

Danielle Kirkman, PhD

dkirkman@udel.edu

Principal Investigator:

Danielle Kirkman, PhD

More Information

Sponsor

University of Delaware

Last update posted

Apr 25, 2019

Last verified

Apr, 2019

Keywords

  • Endothelium, vascular
  • MitoQ
  • Mitochondria
  • Oxidative Stress
  • Chronic Renal Insufficiency
  • Cardiovascular Disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Delaware on 2019-04-25.