Observational StudyCare of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

Background:

Urothelial cancer is cancer of the bladder, ureter, and urethra. Researchers want to better understand what changes in a person s cells and genes cause this cancer to form. This may help them find new ways to treat it.

Objective:

\- To perform DNA sequencing to help researchers learn the differences between normal tissue and tumor tissue. Also, to learn how molecular changes - including gene changes - might help predict the course of disease and how people respond to therapy.

Eligibility:

\- Adults age 18 and older who have or are suspected of having urothelial cancer or an inherited disorder that raises their risk of getting bladder cancer.

Design:

• Participants will be screened with a physical exam. Their medical records and tissue samples will be reviewed.
• Eligible participants will give tissue blocks of their original tumor. The blocks will be put in a tissue bank.
• Participants medical records may be reviewed.
• Participants may have a medical history and physical exam.
• Participants may have blood and urine tests. They may have imaging scans. They may give urine, blood, and saliva samples. These samples may be used in future research.
• If participants need surgery for their cancer, researchers will keep some of the tissue (both tumor and normal tissue). The tissue may be used in future research.
• Participants will go back to the Clinical Center in 6 months. They may give saliva, urine, and blood samples. After 6 months, they will be seen by their local doctor for standard post-surgical visits.
• Participants will be called every 6 months to give health updates.