Recruiting

AMPK Activation

Sponsor:

University of Colorado, Denver

Code:

NCT02391519

Conditions

Pregnancy

IUGR

Preeclampsia

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Collection of myometrial, cord blood, and placental tissue samples

Study Details

Brief summary:

Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.

Conditions

Pregnancy

IUGR

Preeclampsia

Study ID

NCT02391519

Start date

Jan, 2016

Status verified date

Feb, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m)
  • Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation

Exclusion Criteria:

  • Women will be excluded if there are co-existing medical diagnoses that are known to affect vascular parameters (i.e., diabetes mellitus, gestational diabetes, any hypertensive disorder of pregnancy, or a current smoker).
  • Women with multiple gestations and preterm deliveries will also be excluded.

Study Design

Enrollment

84 participants

Anticipated

Interventions and Outcome Measures

Arms

High Altitude (3000 m)

Collection of myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).

Low Altitude (1600 m)

Collection of myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).

Interventions

Collection of myometrial, cord blood, and placental tissue samples

We propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA).

Primary outcome measure

  • Changes in Myometrial artery dimensions [ Time Frame: Up to 1 year ]

Central Contacts and Locations

Central contacts

Lorna Moore, PhD

303-724-7474lorna.moore@ucdenver.edu

Locations

University of Colorado Denver Anschutz Medical Campus

Recruiting

Aurora, Colorado, United States, 80045

Principal Investigator:

Lorna Moore, PhD

More Information

Sponsor

University of Colorado, Denver

Last update posted

Feb 13, 2026

Last verified

Feb, 2026

Keywords

  • Pregnancy
  • High altitude
  • vasoreactivity
  • myometrial arteries

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2026-02-13.