Recruiting

Observational Study

Sponsor:

Duke University

Code:

NCT02418442

Conditions

Rheumatic Joint Disease

Eligibility Criteria

Sex: All

Age: 0 - 21

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Continuation of the CARRA Registry as described in the protocol will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including safety questions.

Conditions

Rheumatic Joint Disease

Study ID

NCT02418442

Start date

Jul, 2015

Status verified date

Oct, 2025

Completion date

Dec, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 21

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Onset of rheumatic disease prior to age 16 years for JIA and onset prior to age 19 years for all other rheumatic diseases (see appendix A).
2. Subject (and/or parent/legal guardian when required) is able to provide written informed consent and willing to comply with study procedures.
3. Subject and/or parent/legal guardian is willing to be contacted in the future by study staff.

Exclusion Criteria:

1\. Greater than 21 years of age at the time of enrollment.

Study Design

Enrollment

20000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Prospectively collect essential data elements from children, adolescents and young adults with pediatric rheumatic diseases [ Time Frame: Approximately 10 years ]
  • Evaluate the safety of therapeutic agents in persons with pediatric onset rheumatic diseases [ Time Frame: Approximately 10 years ]

Central Contacts and Locations

Central contacts

Locations

University of Alabama at Birmingham

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Principal Investigator:

Melissa Mannion, MD

Phoenix Children's Hospital

Recruiting

Phoenix, Arizona, United States, 85254

Contacts

Principal Investigator:

Kaleo Ede, MD

Mattel Children's Hospital at University of California Los Angeles

Recruiting

Los Angeles, California, United States, 90095

Contacts

Principal Investigator:

Deborah McCurdy, MD

Stanford University Medical Center

Recruiting

Palo Alto, California, United States, 94304

Contacts

Principal Investigator:

Joyce Hsu, MD

Rady Children's Hospital San Diego

Recruiting

San Diego, California, United States, 92123

Contacts

Principal Investigator:

Johanna Chang, MD

University of California at San Francisco Medical Center

Recruiting

San Francisco, California, United States, 94143

Contacts

Principal Investigator:

Susan Kim, MD

The Children's Hospital of Colorado

Recruiting

Aurora, Colorado, United States, 80045

Contacts

Principal Investigator:

Katharine Moore, MD

Connecticut Children's Medical Center

Recruiting

Hartford, Connecticut, United States, 06106

Contacts

Jennifer Twachtman-Bassett

Jtwachtman@connecticutchildrens.org

Principal Investigator:

Barbara Edelheit, MD

Childrens National Medical Center

Recruiting

Washington D.C., District of Columbia, United States, 20010

Contacts

Principal Investigator:

Tova Ronis, MD

University of Florida - Shand's Children's Hospital

Recruiting

Gainesville, Florida, United States, 32608

Contacts

Principal Investigator:

Leandra Woolnough, MD

Nemours Children's Hospital

Recruiting

Orlando, Florida, United States, 32827

Contacts

Principal Investigator:

Mary Toth, MD

Johns Hopkins All Children's Hospital

Recruiting

St. Petersburg, Florida, United States, 33701

Contacts

Principal Investigator:

Lilliana Barillas-Arias, MD

Emory Children's Center

Recruiting

Atlanta, Georgia, United States, 30322

Contacts

Principal Investigator:

Sampath Prahalad, MD

Georgia Regents University Medical Center

Recruiting

Augusta, Georgia, United States, 30912

Contacts

Principal Investigator:

Julisa Patel, MD

Ann & Robert H. Lurie Children's Hospital of Chicago

Recruiting

Chicago, Illinois, United States, 60614

Contacts

Principal Investigator:

Marisa Klein-Gitelman, MD

University of Chicago Medical Center

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Principal Investigator:

Melissa Tesher, MD

Indiana University School of Medicine

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Elly Duncan

emckinse@iu.edu

Principal Investigator:

Stacey Tarvin, MD

The University of Iowa Hospitals and Clinics (University of Iowa Children's Hospital)

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Principal Investigator:

Sandy Hong, MD

University of Louisville Schoole of Medicine

Recruiting

Louisville, Kentucky, United States, 40202

Contacts

Principal Investigator:

Alexis Begezda, MD

Tufts Medical Center

Recruiting

Boston, Massachusetts, United States, 02111

Contacts

Principal Investigator:

Trevor Davis, MD

Massachusetts General Hospital for Children

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Principal Investigator:

Marc Natter, MD

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Principal Investigator:

Joyce Chang, MD

University of Michigan

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Principal Investigator:

Smriti Mohan, MD

Helen Devos Children's Hospital

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Principal Investigator:

Cory Stingl, MD

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55454

Contacts

Principal Investigator:

Colleen Correll, MD

Mayo Clinic

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Principal Investigator:

Matthew Basiaga, DO

University of Mississippi Medical Center

Recruiting

Jackson, Mississippi, United States, 39216

Contacts

Kaylee Rhodes

kdrhodes@umc.edu

Principal Investigator:

Yasmin Elzaki, MD

Children's Mercy Hospital

Recruiting

Kansas City, Missouri, United States, 64108

Contacts

Principal Investigator:

Ashley Cooper, MD

Saint Louis Children's Hospital

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Principal Investigator:

Kevin Baszis, MD

Hackensack University Medical Center

Recruiting

Hackensack, New Jersey, United States, 07601

Contacts

Principal Investigator:

Jennifer Weiss, MD

Goryeb Children's Hospital

Recruiting

Morristown, New Jersey, United States, 07960

Contacts

Principal Investigator:

Simona Nativ, MD

Robert Wood Johnson Medical School

Recruiting

New Brunswick, New Jersey, United States, 08901

Contacts

Principal Investigator:

Nandini Moorthy, MD

The Pediatric Specialty Center at Saint Barnabas

Recruiting

West Orange, New Jersey, United States, 07052

Contacts

Principal Investigator:

Elizabeth Chalom, MD

Albany Medical College

Recruiting

Albany, New York, United States, 122089

Contacts

Principal Investigator:

Suhas Ganguli

Cohen Children's Medical Center of New York

Recruiting

Lake Success, New York, United States, 11042

Contacts

Principal Investigator:

Heather Walters, MD

Hospital for Special Surgery

Recruiting

New York, New York, United States, 10021

Contacts

Principal Investigator:

Karen Onel, MD

Columbia University Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Principal Investigator:

Lisa Imundo, MD

Children's Hospital at Montefiore

Recruiting

New York, New York, United States, 10467

Contacts

Emily "Mimi" Gillies

egillies@montefiore.org

Principal Investigator:

Dawn Wahezi, MD

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Principal Investigator:

Christina Schutt, DO

University of North Carolina at Chapel Hill

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

Carolina Pastrana-Medina

919-564-5220carol825@med.unc.edu

Principal Investigator:

Eveline Wu, MD

Levine Children's Hospital / Carolinas Medical Center

Recruiting

Charlotte, North Carolina, United States, 28203

Contacts

Principal Investigator:

Thomas Griffin, MD

Duke Children's Hospital & Health Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Principal Investigator:

Heather Van Mater, MD

Wake Forest Baptist Brenner Children's Hospital

Recruiting

Winston-Salem, North Carolina, United States, 27012

Contacts

Principal Investigator:

Onengiya Harry, MD

Sanford Health

Recruiting

Fargo, North Dakota, United States, 58122

Contacts

Principal Investigator:

Grant Syverson, MD

Akron Children's Hospital

Recruiting

Akron, Ohio, United States, 44308

Contacts

Principal Investigator:

Kate Cook, DO

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Contacts

Principal Investigator:

Sheila Angeles-Han, MD

Metrohealth Medical Center

Recruiting

Cleveland, Ohio, United States, 44109

Contacts

Principal Investigator:

Hulya Bukulmez, MD

Cleveland Clinic Foundation

Recruiting

Cleveland, Ohio, United States, 44195

Contacts

Principal Investigator:

Angela Robinson, MD

Nationwide Children's Hospital

Recruiting

Columbus, Ohio, United States, 43205

Contacts

Principal Investigator:

Stacy Ardoin, MD

Randall Children's Hospital at Legacy Emanuel

Recruiting

Portland, Oregon, United States, 97227

Contacts

Principal Investigator:

Daniel Kingsbury, MD

Penn State Children's Hospital

Recruiting

Hershey, Pennsylvania, United States, 17033

Contacts

Principal Investigator:

Timothy Hahn, MD

Children's Hospital of Philadelphia

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Principal Investigator:

Pamela Weiss, MD

Saint Christopher's Hospital for Children

Recruiting

Philadelphia, Pennsylvania, United States, 19134

Contacts

Principal Investigator:

Dana Toib, MD

Children's Hospital of Pittsburgh UPMC

Recruiting

Pittsburgh, Pennsylvania, United States, 15224

Contacts

Principal Investigator:

Margalit Rosenkranz, MD

Hasbro Children's Hospital

Recruiting

Providence, Rhode Island, United States, 02903

Contacts

Principal Investigator:

Ali Yalcindag, MD

Medical University of South Carolina Children's Hospital

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Principal Investigator:

Natasha Ruth, MD

Monroe Carrell Jr. Children's Hospital at Vanderbilt

Recruiting

Nashville, Tennessee, United States, 37232

Contacts

Principal Investigator:

Thomas Graham, MD

University of Texas Southwestern Medical Center Dallas

Recruiting

Dallas, Texas, United States, 75219

Contacts

Principal Investigator:

Elizabeth Sloan, MD

Baylor College of Medicine Pediatric Immunology Allergy Rheumatology

Recruiting

Houston, Texas, United States, 77030

Contacts

Principal Investigator:

Marietta DeGuzman, MD

University of Utah Hospitals and Clinics (Primary Children's Hospital)

Recruiting

Salt Lake City, Utah, United States, 84113

Contacts

Principal Investigator:

Christi Inman, MD

University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05401

Contacts

Principal Investigator:

Matthew Hollander, MD

Children's Hospital of the King's Daughters

Recruiting

Norfolk, Virginia, United States, 23507

Contacts

Principal Investigator:

Cassyanne Aguiar, MD

Seattle Children's Hospital

Recruiting

Seattle, Washington, United States, 98105

Contacts

Principal Investigator:

Kabita Nanda, MD

University of Wisconsin, American Family Children's Hospital

Recruiting

Madison, Wisconsin, United States, 53792

Contacts

Principal Investigator:

Dominic Co, MD, PhD

Children's Hospital Of Wisconsin

Recruiting

Wauwatosa, Wisconsin, United States, 53226

Contacts

Principal Investigator:

Sara Sabbagh, DO

University of Calgary - Alberta Children's Hospital

Recruiting

Calgary, Alberta, Canada, AB T38 6A8

Contacts

Principal Investigator:

Marinka Twilt, MD, PhD

University of Manitoba - Children's Hospital of Manitoba

Recruiting

Winnipeg, Manitoba, Canada, R3E 3P4

Contacts

Principal Investigator:

Lily Lim, PhD

IWK Health Center

Recruiting

Halifax, Nova Scotia, Canada, NS B3K 6R8

Contacts

Principal Investigator:

Adam Huber, MD

The Hospital for Sick Children

Recruiting

Toronto, Ontario, Canada

Contacts

Principal Investigator:

Brian Feldman, MD

More Information

Sponsor

Duke University

Last update posted

Aug 27, 2026

Last verified

Oct, 2025

Keywords

  • Systemic Arthritis
  • Oligoarthritis
  • Polyarthritis (Rheumatoid Factor Negative)
  • Polyarthritis (Rheumatoid Factor Positive)
  • Psoriatic Arthritis
  • Enthesitis Related Arthritis (ERA)
  • Undifferianted Arthritis
  • CARRA Consensus Treatment Plans

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Duke University on 2026-08-27.